Fig. 6From: Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in ratsBBG administration induces proliferation and decreases apoptosis in tubular cells in UUO. a Graphical representation of a semi-quantitative analysis of the proliferation index (percentage of PCNA+ cells) in renal cortex and (d) medulla. The graphics show aligned dot plot and mean ± SEM of 20 captured images of each kidney in the different experimental groups. * p < 0.05 vs UUO-BBG and both SHAM groups. # p < 0.05 vs UUO-V and both SHAM groups. b Representative cortical immunostaining from UUO-V and c UUO-BBG (Bar = 50 μm). e Representative medullary immunostaining from UUO-V and (f) UUO-BBG (Bar = 50 μm). g Graphical representations of a semi-quantitative analysis of the apoptotic index (percentage of TUNEL+ cells) in renal cortex and (j) medulla. The graphics show aligned dot plot and mean ± SEM of 20 captured images of each kidney in the different experimental groups. * p < 0.05 vs UUO-BBG and both SHAM groups. h Representative cortical immunostaining from UUO-V and (i) UUO-BBG (Bar = 50 μm). k Representative medullary immunostaining from UUO-V and l UUO-BBG (Bar = 100 μm). All pictures of the sham control groups are shown in the supplementary materialBack to article page