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Fig. 6 | BMC Nephrology

Fig. 6

From: Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in rats

Fig. 6

BBG administration induces proliferation and decreases apoptosis in tubular cells in UUO. a Graphical representation of a semi-quantitative analysis of the proliferation index (percentage of PCNA+ cells) in renal cortex and (d) medulla. The graphics show aligned dot plot and mean ± SEM of 20 captured images of each kidney in the different experimental groups. * p < 0.05 vs UUO-BBG and both SHAM groups. # p < 0.05 vs UUO-V and both SHAM groups. b Representative cortical immunostaining from UUO-V and c UUO-BBG (Bar = 50 μm). e Representative medullary immunostaining from UUO-V and (f) UUO-BBG (Bar = 50 μm). g Graphical representations of a semi-quantitative analysis of the apoptotic index (percentage of TUNEL+ cells) in renal cortex and (j) medulla. The graphics show aligned dot plot and mean ± SEM of 20 captured images of each kidney in the different experimental groups. * p < 0.05 vs UUO-BBG and both SHAM groups. h Representative cortical immunostaining from UUO-V and (i) UUO-BBG (Bar = 50 μm). k Representative medullary immunostaining from UUO-V and l UUO-BBG (Bar = 100 μm). All pictures of the sham control groups are shown in the supplementary material

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