Table 2 Summary data of haemoglobin, ferritin, iron dose (weekly) and erythropoeitin dose (weekly) for each monthly interval. Differences from baseline are displayed for each variable at every timepoint, along with testing for statistical significance (see statistical analysis section). CI, confidence interval; ESA, erythropoeisis stimulating agent
From: Conversion of haemodialysis patients from iron sucrose to iron isomaltoside: a real-world experience
Haemoglobin (g/L) | Ferritin (mcg/L) | Weekly dose of Iron (mg) | Weekly dose of EPO (units) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Time point from baseline (months) | Mean value | Mean difference | 95% CI of difference | P Value | Mean value | Mean difference | 95% CI of difference | P Value | Median dose per week | Rank Sum | Rank Sum difference | P Value | Median dose per week | Rank Sum | Rank Sum difference | P Value |
-6 | 108.8 | 0.07 | −2.97 to 3.10 | > 0.99 | 354.0 | −18.6 | −58.7 to 21.6 | 0.85 | 25.0 | 1682 | 219.5 | 0.72 | 8000 | 1818 | −85.50 | > 0.99 |
−5 | 110.6 | −1.74 | −3.95 to 0.46 | 0.21 | 365.8 | −30.4 | −68.3 to 7.6 | 0.20 | 25.0 | 1723 | 178.0 | > 0.99 | 8000 | 1847 | − 115.0 | > 0.99 |
−4 | 108.9 | −0.02 | −1.93 to 1.89 | > 0.99 | 327.0 | 8.5 | −19.3 to 36.3 | 0.99 | 25.0 | 1758 | 143.0 | > 0.99 | 7500 | 1781 | −49.00 | > 0.99 |
−3 | 108.4 | 0.53 | −1.56 to 2.62 | > 0.99 | 336.4 | −1.0 | −33.3 to 31.3 | > 0.99 | 25.0 | 1772 | 129.5 | > 0.99 | 6000 | 1755 | −22.50 | > 0.99 |
−2 | 107.7 | 1.24 | −0.77 to 3.25 | 0.51 | 362.1 | −26.6 | −67.0 to 13.8 | 0.42 | 25.0 | 1770 | 131.5 | > 0.99 | 8000 | 1897 | − 165.0 | > 0.99 |
−1 | 110.6 | −1.74 | −3.95 to 0.46 | 0.21 | 267.5 | 68.0 | 29.4 to 106.6 | < 0.01 | 50.0 | 1762 | 139.5 | > 0.99 | 8000 | 1619 | 113.5 | > 0.99 |
Baseline (T0) | 108.9 | – | – | – | 335.5 | – | – | – | 33.3 | 1901 | – | – | 7833 | 1732 | – | – |
1 | 112.9 | −3.96 | −7.97 to 0.05 | 0.06 | 332.8 | 2.6 | −36.2 to 41.5 | > 0.99 | 50.0 | 2165 | − 263.5 | 0.24 | 9000 | 2009 | − 276.5 | 0.18 |
2 | 111.7 | −2.77 | −6.82 to 1.27 | 0.37 | 347.2 | −11.7 | −55.0 to 31.6 | > 0.99 | 50.0 | 1937 | −36.00 | > 0.99 | 9000 | 1947 | − 214.5 | 0.83 |
3 | 113.1 | −4.20 | −8.32 to −0.08 | 0.04 | 331.6 | 3.8 | −37.7 to 45.4 | > 0.99 | 50.0 | 1981 | −79.50 | > 0.99 | 10,000 | 2099 | − 367.0 | 0.01 |
4 | 112.5 | −3.63 | −8.00 to 0.75 | 0.17 | 361.6 | −26.1 | −76.0 to 23.7 | 0.72 | 25.0 | 1744 | 157.5 | > 0.99 | 8000 | 1873 | − 140.5 | > 0.99 |
5 | 114.2 | −5.34 | −9.86 to −0.83 | 0.01 | 361.0 | −25.5 | −72.6 to 21.6 | 0.68 | 25.0 | 1707 | 194.0 | > 0.99 | 8000 | 1818 | −86.00 | > 0.99 |
6 | 113.8 | −4.88 | −9.49 to −0.26 | 0.03 | 377.9 | −42.4 | −98.0 to 13.2 | 0.25 | 50.0 | 1781 | 120.5 | > 0.99 | 6000 | 1444 | 288.5 | 0.13 |
7 | 113.9 | −5.00 | −9.74 to −0.26 | 0.03 | 394.6 | −59.1 | − 126.6 to 8.4 | 0.13 | 25.0 | 1748 | 153.0 | > 0.99 | 9000 | 1987 | − 254.5 | 0.33 |
8 | 113.7 | −4.77 | −9.39 to −0.15 | 0.04 | 387.4 | −51.9 | − 113.9 to 10.1 | 0.16 | 25.0 | 1747 | 154.0 | > 0.99 | 8000 | 1935 | − 202.5 | > 0.99 |
9 | 111.6 | −2.71 | −7.19 to 1.76 | 0.54 | 410.4 | −74.9 | − 154.0 to 4.1 | 0.07 | 50.0 | 1776 | 125.5 | > 0.99 | 8000 | 1918 | − 186.0 | > 0.99 |
10 | 110.2 | −1.34 | −5.67 to 2.99 | 0.99 | 378.7 | −43.2 | −103.1 to 16.7 | 0.31 | 25.0 | 1773 | 128.0 | > 0.99 | 8000 | 1919 | −186.5 | > 0.99 |
11 | 112.2 | −3.26 | −7.48 to 0.96 | 0.24 | 373.2 | −37.8 | −96.1 to 20.6 | 0.44 | 50.0 | 1708 | 193.0 | > 0.99 | 7500 | 1816 | −84.00 | > 0.99 |
12 | 111.3 | −2.41 | −7.04 to 2.22 | 0.73 | 354.3 | −18.9 | −75.2 to 37.5 | 0.99 | 50.0 | 1770 | 131.5 | > 0.99 | 6000 | 1561 | 171.0 | > 0.99 |