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Table 1 Baseline clinical characteristics in IMN patients with and without DM

From: The impact of coexisting diabetes mellitus on clinical outcomes in patients with idiopathic membranous nephropathy: a retrospective observational study

Clinical characteristics

Non-DM

(n = 164)

DM

(n = 42)

P-value

Age (years)

48 ± 15

60 ± 9

< 0.001

male (n, %)

94(57.3)

21 (50.0)

0.394

SBP (mmHg)

134 ± 20

137 ± 21

0.505

DBP (mmHg)

82 ± 12

78 ± 11

0.062

Hypertension (n, %)

71 (43.3)

17 (40.5)

0.742

Glomerular hematuria (n, %)

15 (9.1)

3 (7.1)

0.682

eGFR (ml/min/1.73m2)

91.5 ± 21.9

76.1 ± 27.1

0.001

Serum creatinine (μmol/L)

84 ± 45

96 ± 55

0.134

Proteinuria (g/24 h)

5.5 ± 3.8

7.2 ± 6.0

0.084

Albuminuria (g/24 h)

3.1 ± 2.1

3.4 ± 2.4

0.522

uPCR (mg/gCr)

4.4 ± 3.6

5.9 ± 4.9

0.074

uACR (mg/gCr)

2.4 ± 1.9

2.8 ± 2.2

0.173

Serum albumin (g/L)

22.4 ± 7.4

22.4 ± 5.7

0.943

Hemoglobin (g/L)

129.3 ± 20.2

120.3 ± 21.6

0.012

Blood uric acid (μmol/L)

427.2 ± 120.5

402.8 ± 103.8

0.232

Cholesterol (mmol/L)

8.7 ± 3.0

8.2 ± 2.5

0.349

Triglyceride (mmol/L)

3.1 ± 2.2

3.3 ± 2.1

0.588

HDL (mmol/L)

1.5 ± 0.5

1.5 ± 0.5

0.652

LDL (mmol/L)

5.5 ± 2.0

5.1 ± 1.7

0.233

Glycosylated hemoglobin (%)

5.6 ± 0.5

6.5 ± 1.0

< 0.001

Type of Diabetes (n, %)

Type 1 Diabetes

–

1 (2.4)

–

Type 2 Diabetes

–

31 (97.6)

–

Steroid diabetes

–

10 (23.8)

 

Duration of diabetes (n, %)

New-onset diabetes

–

27 (64.3)

–

Previous diabetes

–

15 (35.7)

–

Therapeutic regimen for DM (n, %)

Oral hypoglycemic drugs

–

27 (64.3)

–

Insulin

–

1 (2.4)

–

Lifestyle management

–

14 (33.3)

–

  1. Data were expressed as mean ± SD (standard deviation), medians (interquartile range), or numbers (%)
  2. DM diabetes mellitus, SBP systolic blood pressure, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, uPCR urine protein creatinine ratio, uACR urine albumin creatinine ratio, HDL high density lipoprotein, LDL low density lipoprotein