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Table 4 Factors predicting renal function deterioration in Cox regression models

From: The impact of coexisting diabetes mellitus on clinical outcomes in patients with idiopathic membranous nephropathy: a retrospective observational study

Variables

Cox univariate analysis

Cox multivariate analysis

HR (95% CI)

p-value

HR (95% CI)

p-value

DM

2.398 (1.327,4.333)

0.004

1.988 (1.069,3.695)

0.030

Age

1.056 (1.033,1.080)

< 0.001

eGFR

0.987 (0.977,0.996)

0.005

0.991 (0.981,1.002)

0.109

Albuminuria

0.953 (0.910,0.998)

0.039

0.964 (0.917,1.014)

0.160

Hemoglobin

0.984 (0.972,0.996)

0.010

0.991 (0.977,1.004)

0.185

Interstitial fibrosis

1.944 (1.108,3.411)

0.020

1.996 (1.127,3.533)

0.018

Therapeutic regimen

 

0.208

 

0.182

Supportive therapy

Reference

Reference

Reference

Reference

CTX

1.951 (0.619,6.151)

0.254

1.034 (0.312,3.424)

0.956

CsA

2.364 (1.037,5.390)

0.041

2.201 (0.941,5.149)

0.069

FK506

2.214 (0.774,6.330)

0.138

2.124 (0.731,6.173)

0.166

Other*

0.557 (0.068,4.530)

0.584

0.550 (0.067,4.548)

0.579

  1. Considering the existence of collinearity between age and eGFR, we only included eGFR in Cox Multivariate Analysis. The variables were selected in the models in an “enter” manner
  2. HR hazard ratio, CI Confidence interval, DM diabetes mellitus, eGFR estimated Glomerular Filtration Rate, CTX cyclophosphamide, CsA ciclosporin, FK506 tacrolimus
  3. * including mycophenolate mofetil and glucocorticoids, rituximab and glucocorticoids