Fig. 2

Proteinuria in the 8-Week and 12-Week PAN Models. a Protein concentration (mg/24 h) in urine over the 8-week PAN study (*p < 0.05 day 28 for RCI 30 IU/kg versus saline; 2-way ANOVA, Bonferroni’s post hoc comparison). b Protein concentration (mg/24 h) in urine over the 12-week study (*p < 0.05 day 35 for 60 IU/kg RCI; **p < 0.001 day 42 for 30 IU/kg RCI; ***p < 0.0001 day 42 for RCI 60 IU/kg; all versus saline; 2-way ANOVA, Bonferroni’s post hoc comparisons). In both panels, values are mean ± standard error of the mean. Abbreviations: ANOVA, analysis of variance; MP, methylprednisolone; PAN, puromycin aminonucleoside; RCI, repository corticotropin injection