Table 2 Histopathological evaluation injury scores of H&E-stained kidney sections for the 8-week and 12-week PAN models

Pathology Report

Fibrosis

2.3 ± 0.5

2.9 ± 0.8

^a1.6 ± 0.5

2.3 ± 0.7

2.1 ± 1.0

^a1.7 ± 0.5

^a1.3 ± 0.7

Interstitial Inflammation

1.4 ± 0.5

1.3 ± 0.5

1.0 ± 0.0

1.4 ± 0.5

1.1 ± 0.3

1.0 ± 0.0

^a0.6 ± 0.7

Tubular Injury

2.6 ± 0.5

2.8 ± 0.9

^a1.5 ± 0.5

2.4 ± 0.5

2.4 ± 0.7

^a1.7 ± 0.5

^a1.3 ± 0.5

Glomerular Changes

2.5 ± 0.9

3.3 ± 0.7

^a1.8 ± 0.5

2.8 ± 1.0

3.0 ± 0.9

^a2.3 ± 0.5

^a2.0 ± 0.9

Quantitative

Total Kidney Injury Score

8.8 ± 2.1

10.1 ± 2.7

*5.9 ± 1.4

8.8 ± 2.4

8.6 ± 2.9

6.7 ± 1.4

*5.1 ± 2.5