Fig. 1

Representative immunohistochemical findings of Ki67 and hematoxylin counterstain (× 100) (a), and the differences in the mean labeling index of Ki67 protein expression (b) among the four groups: Control NP rats, Control HP rats, CKD NP rats, and CKD HP rats. a Nuclear Ki67 expression. Many nuclei in CKD HP were positively stained for the Ki67 protein. b In CKD HP rats, Ki67 expression was significantly increased compared with that of the other groups, then the number of Ki67 positive cells tended to increase in the Control NP rats and CKD NP rats, though not significantly different. Number of animals: Control NP, 6; Control HP, 6; CKD NP, 6; and CKD HP, 6. Results are presented as the mean ± SD. The mean difference is significant at the 0.0083 level for Bonferroni test