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Table 2 AAC score, mGFR and some markers of arteriosclerosis at baseline and after 12 months of exercise training

From: Twelve months of exercise training did not halt abdominal aortic calcification in patients with CKD – a sub-study of RENEXC-a randomized controlled trial

 

Balance Group

Strength Group

Whole Group

Baseline

12 months

P

Baseline

12 months

P

Baseline

12 months

P

AAC, score

8.5(0–13)

9.5(1–14)

< 0.001

5(1–12)

6(2–13)

0.002

5(0–12.5)

7(2–14)

< 0.001

mGFR, mL/min/1.73m2

22.3 ± 6.9

21.1 ± 7.8

0.003

23.0 ± 9.1

22.0 ± 9.7

0.01

22.6 ± 8.0

21.6 ± 8.8

< 0.001

Blood pressure, mmHg

129 ± 17/75 ± 10

132 ± 17/75 ± 10

0.1

129 ± 15/74 ± 9

129 ± 13/74 ± 8

0.8

129 ± 16/ 75 ± 10

130 ± 15/ 75 ± 9

0.4

Lipids and lipoproteins

 P-Triglycerides, mmol/mL

1.8 ± 1.0

1.8 ± 1.0

0.7

1.8 ± 1.0

1.8 ± 1.1

0.8

1.8 ± 1.0

1.8 ± 1.0

0.2

 P-Total cholesterol, mmol/L

4.8 ± 1.2

4.6 ± 1.1

0.05

4.7 ± 1.3

4.7 ± 1.3

0.6

4.8 ± 1.2

4.7 ± 1.2

0.5

 P-HDL-C, mmol/L

1.3 ± 0.5

1.3 ± 0.4

0.5

1.2 ± 0.3

1.2 ± 0.4

0.6

1.3 ± 0.4

1.3 ± 0.4

0.2

 P-LDL-C, mmol/L

3.0 ± 1.0

3.1 ± 2.4

0.5

2.9 ± 1.1

3.0 ± 1.1

0.5

2.9 ± 1.0

3.1 ± 1.9

0.7

 Lipoprotein (a), nmol/L

99(41–209)

45(22–147)

< 0.001

90(29–315)

59(13–242)

0.04

96(31–238)

47(19–188)

< 0.001

Pro-calcific markers

 P-FGF23, ng/mL

1.8(0.6–9.5)

2.8(0.6–12.3)

0.4

1.8(0.4–6.8)

3.2(1.3–13.0)

0.4

1.8(0.5–9.2)

3.1(0.7–14.1)

0.2

 P-Phosphate, mmol/L

1.2 ± 0.2

1.2 ± 0.2

0.4

1.1 ± 0.2

1.1 ± 0.3

0.2

1.1 ± 0.2

1.2 ± 0.2

0.06

 P-Calcium, mmol/L

2.3 ± 0.1

2.3 ± 0.1

0.6

2.3 ± 0.1

2.3 ± 0.1

1

2.3 ± 0.1

2.3 ± 0.1

0.7

 P-PTH, pmol/L

11(9.3–17)

14(8.7–20)

0.2

10(7.4–16)

11(7.7–21)

0.03

11(8.1–17)

13(7.9–20)

0.01

Anti-calcific markers

 P-1,25(OH)2D3, nmol/L

67 ± 31

73 ± 31

0.2

62 ± 23

67 ± 27

0.04

64 ± 27

70 ± 29

0.04

 P-Fetuin-A, g/L

0.9 ± 0.3

1.0 ± 0.2

0.02

1.0 ± 0.3

1.0 ± 0.2

0.9

1.0 ± 0.3

1.0 ± 0.2

0.2

Inflammatory markers

 P-IL6, pg/mL

1.7(1–2.8)

2.1(1–3.1)

0.2

2.3(1.6–4)

2.2(1.5–3.7)

0.6

2.0(1.2–3.3)

2.1(1.3–3.3)

0.2

 P-CRP (mg/L)

2.9(1.3–5.9)

3(1.2–5)

0.9

3.5(1.5–5.9)

3(1.5–6)

0.8

3.1(1.4–6.2)

3(1.4–6)

0.8

 P-Albumin (g/L)

37.7 ± 2.8

36.8 ± 5.3

0.3

36.8 ± 3.6

36.0 ± 3.3

0.1

37.3 ± 3.2

36.4 ± 4.5

0.05

  1. Data presented as mean ± SD or median(25th–75th percentile)
  2. AAC Abdominal aortic calcification, mGFR Measured Glomerular Filtration Rate, P Plasma, FGF23 Fibroblast growth factor 23, PTH Parathyroid hormone, IL6 Interleukin 6, CRP C-reactive protein, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol, 95%CI 95% confidence interval