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Table 2 Multivariable Cox proportional hazard models of sST2 and sLR11 for all-cause mortality and MACCEs

From: Prognostic value of soluble ST2 and soluble LR11 on mortality and cardiovascular events in peritoneal dialysis patients

 

Crude HR (95% CI)

aAdjusted HR 1 (95% CI)

bAdjusted HR 2 (95% CI)

All-cause mortality

sST2

csST2 ≥ 70.9 ng/mL (vs. < 70.9)

6.715 (1.749–25.784)

9.638 (2.180–42.602)

10.144 (2.156–47.734)

dsST2 ≥ cut-off (vs. <cut-off)

9.459 (2.034–43.988)

12.189 (2.408–61.696)

5.551 (1.360–22.660)

  sST2 (per 1 SD increase)

2.179 (1.351–3.515)

1.921 (1.151–3.207)

1.943 (1.124–3.359)

sLR11

csLR11 ≥ 15.2 ng/mL (vs. < 15.2)

0.791 (0.258–2.422)

0.630 (0.187–2.130)

0.601 (0.168–2.145)

esLR11 ≥ cut-off (vs. <cut-off)

1.271 (0.415–3.896)

0.944 (0.271–3.286)

0.859 (0.211–3.503)

  sLR11 (per 1 SD increase)

0.884 (0.503–1.555)

0.763 (0.397–1.467)

0.719 (0.356–1.451)

MACCEs

sST2

csST2 ≥ 70.9 ng/mL (vs. < 70.9)

2.056 (1.259–6.940)

4.623 (1.743–12.263)

3.928 (1.413–10.918)

dsST2 ≥ cut-off (vs. <cut-off)

3.776 (1.546–9.218)

5.445 (2.020–14.679)

4.609 (1.608–13.208)

  sST2 (per 1 SD increase)

1.748 (1.179–2.592)

1.683 (1.120–2.529)

1.630 (1.073–2.477)

sLR11

csLR11 ≥ 15.2 ng/mL (vs. < 15.2)

0.743 (0.321–1.723)

0.736 (0.29301.849)

0.737 (0.271–2.002)

esLR11 ≥ cut-off (vs. <cut-off)

1.278 (0.551–2.965)

1.315 (0.532–3.250)

1.315 (0.487–3.548)

  sLR11 (per 1 SD increase)

0.951 (0.634–1.428)

0.947 (0.606–1.481)

0.927 (0.577–1.490)

  1. Abbreviations: CI confidence interval, HR hazard ratio, MACCE major adverse cardiac and cerebrovascular event, PD peritoneal dialysis, SD standard deviation, sLR11 soluble form of low-density lipoprotein receptor relative with 11 ligand-binding repeats, sST2 soluble form of suppression of tumorigenicity 2
  2. aAdjusted HR 1 was calculated after adjustment of age, sex, diabetes mellitus, and history of cardiovascular disease
  3. bAdjusted HR 2 was calculated after adjustment of age, sex, PD duration, diabetes mellitus, history of cardiovascular disease, smoking status, body mass index, and hemoglobin concentrations
  4. cPatients were dichotomized based on median values of sST2 (70.9 ng/mL) and sLR11 (15.2 ng/mL), respectively
  5. dPatients were categorized into two groups based on the calculated cut-off of sST2 for all-cause mortality (75.8 ng/mL) and MACCEs (72.5 ng/mL)
  6. ePatients were categorized into two groups based on the calculated cut-off of sLR11 (14.9 ng/mL) for all-cause mortality and MACCEs
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BMC Nephrology

ISSN: 1471-2369

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