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Table 3 NRIs, IDIs, and c Statistics for prediction of all-cause mortality and MACCE

From: Prognostic value of soluble ST2 and soluble LR11 on mortality and cardiovascular events in peritoneal dialysis patients

ModelsNRIaPIDIaPc StatisticsaP
(95% CI) (95% CI)   
All-cause mortality
 Base modelReference Reference 0.729 
 Model 10.598 (0.039 to 1.156)0.040.029 (− 0.0068 to 0.0655)0.110.8630.48
 Model 20.225 (− 0.372 to 0.821)0.460.005 (−0.014 to 0.024)0.610.7310.19
 Model 30.477 (−0.106 to 1.059)0.110.027 (−0.0005 to 0.060)0.100.7650.71
MACCE
 Base modelReference Reference 0.718 
 Model 10.385 (−0.099 to 0.870)0.120.008 (−0.014 to 0.030)0.490.8010.46
 Model 20.133 (−0.357 to 0.627)0.590.019 (−0.013 to 0.050)0.240.7050.33
 Model 30.007 (−0.481 to 0.495)0.90.001 (−0.002 to 0.007)0.820.7200.47
  1. Base model: adjusted for age, sex, PD duration, smoking, diabetes mellitus, cardiovascular disease, body mass index, and hemoglobin
  2. Model 1: base model + sST2
  3. Model 2: base model + sLR11
  4. Model 3: base model + hs-CRP
  5. Abbreviations: CI confidence interval, IDI integrated discrimination improvement, hs-CRP high-sensitivity C-reactive protein, PD peritoneal dialysis, MACCE major adverse cardiac and cerebrovascular event, NRI net reclassification index, sLR11 soluble form of low-density lipoprotein receptor relative with 11 ligand-binding repeats, sST2 soluble form of suppression of tumorigenicity 2
  6. avs. Base model