Prognostic value of soluble ST2 and soluble LR11 on mortality and cardiovascular events in peritoneal dialysis patients

Table 3 NRIs, IDIs, and c Statistics for prediction of all-cause mortality and MACCE

Models	NRI	^aP	IDI	^aP	c Statistics	^aP
Models	(95% CI)		(95% CI)
All-cause mortality
Base model	Reference		Reference		0.729
Model 1	0.598 (0.039 to 1.156)	0.04	0.029 (− 0.0068 to 0.0655)	0.11	0.863	0.48
Model 2	0.225 (− 0.372 to 0.821)	0.46	0.005 (−0.014 to 0.024)	0.61	0.731	0.19
Model 3	0.477 (−0.106 to 1.059)	0.11	0.027 (−0.0005 to 0.060)	0.10	0.765	0.71
MACCE
Base model	Reference		Reference		0.718
Model 1	0.385 (−0.099 to 0.870)	0.12	0.008 (−0.014 to 0.030)	0.49	0.801	0.46
Model 2	0.133 (−0.357 to 0.627)	0.59	0.019 (−0.013 to 0.050)	0.24	0.705	0.33
Model 3	0.007 (−0.481 to 0.495)	0.9	0.001 (−0.002 to 0.007)	0.82	0.720	0.47

Base model: adjusted for age, sex, PD duration, smoking, diabetes mellitus, cardiovascular disease, body mass index, and hemoglobin
Model 1: base model + sST2
Model 2: base model + sLR11
Model 3: base model + hs-CRP
Abbreviations: CI confidence interval, IDI integrated discrimination improvement, hs-CRP high-sensitivity C-reactive protein, PD peritoneal dialysis, MACCE major adverse cardiac and cerebrovascular event, NRI net reclassification index, sLR11 soluble form of low-density lipoprotein receptor relative with 11 ligand-binding repeats, sST2 soluble form of suppression of tumorigenicity 2
^avs. Base model