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Table 4 Cox proportional hazard ratios for mortality due to each cause of death, and the association with body mass index and history of cardiovascular disease in patients with chronic kidney disease

From: Impact of lower body mass index on risk of all-cause mortality and infection-related death in Japanese chronic kidney disease patients

 

CVDs

Infections

Malignancies

Univariate

SHR

95% CI

P

SHR

95% CI

P

SHR

95% CI

P

BMI group, lower

1.23

0.94

1.62

0.130

1.62

1.12

2.35

0.010

1.05

0.73

1.53

0.782

Model 1

SHR

95% CI

P

SHR

95% CI

P

SHR

95% CI

P

Age group, elder

3.17

2.01

4.99

<.0001

6.37

3.43

11.81

<.0001

3.22

1.74

5.96

<.0001

BMI group, lower

1.14

0.86

1.52

0.368

1.49

1.00

2.20

0.048

0.99

0.67

1.46

0.952

CVD history, yes

3.86

2.03

7.33

<.0001

2.82

1.24

6.42

0.013

1.91

0.68

5.40

0.222

Smoking, yes

2.82

1.32

6.05

0.008

2.22

0.73

6.81

0.161

2.79

1.00

7.84

0.051

Model 2

SHR

95% CI

P

SHR

95% CI

P

SHR

95% CI

P

Age group, elder

2.80

1.82

4.31

<.0001

5.82

3.10

10.93

<.0001

2.90

1.49

5.65

0.002

BMI group, lower

1.16

0.88

1.53

0.290

1.46

1.02

2.10

0.039

1.00

0.69

1.44

0.983

CVD history, yes

3.55

1.90

6.64

<.0001

2.73

1.22

6.11

0.015

1.83

0.67

4.99

0.240

MBP group, higher

0.79

0.60

1.03

0.081

0.65

0.39

1.07

0.090

0.78

0.52

1.18

0.245

Model 3

SHR

95% CI

P

SHR

95% CI

P

SHR

95% CI

P

Age group, elder

3.44

2.34

5.08

<.0001

7.05

3.88

12.83

<.0001

3.52

1.80

6.91

<.0001

BMI group, lower

1.21

0.91

1.60

0.192

1.56

1.05

2.33

0.029

1.12

0.75

1.67

0.576

CKD stage, higher

1.07

0.88

1.32

0.493

1.03

0.78

1.36

0.848

0.89

0.68

1.17

0.392

Proteinuria, yes

2.05

1.01

4.16

0.046

1.80

0.72

4.49

0.209

1.03

0.38

2.85

0.947

  1. Adjusted risks for all-cause mortality and the cause specific mortality were calculated. BMI Q4 was used as reference. Bold font indicates statistical significance (P < 0.05)
  2. Covariates in multivariable-adjusted models included age, body mass index, and additional two factors based on different models. Abbreviations: SHR subdistribution hazard ratio, 95% CI 95% confidence interval, BMI body mass index, CVD cardiovascular disease, MBP mean blood pressure, CKD chronic kidney disease
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BMC Nephrology

ISSN: 1471-2369

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