Table 1 Characteristics of the 4 patients with a kidney injury related to Parvovirus B19 primary infection. (NA: not available)
Case #1 | Case #2 | Case #3 | Case #4 | |
|---|---|---|---|---|
Gender | Female | Female | Male | Female |
Age (years) | 42 | 42 | 28 | 19 |
Past medical history | None | None | None | Sickle cell disease |
Clinical examination | Diffuse edema and pleural effusion | Acute nephritic syndrome, fever, rash | Fever, diarrhea, pallor | Edema, pallor |
Serum creatinine (mg/dL) | 1.17 | 1.33 | 6.14 | 1 |
Serum albumin (g/dL) | 2.5 | 3.3 | 3.4 | 2,4 |
Proteinuria (g/24 h) | 9.6 | 1 | 0.8 | 3,5 |
Hemoglobin (g/dL) | 10.7 | 8.4 | 11.9 | 6,3 |
Reticulocytes (G/L) | 35 | 82 | 4 | 136 |
C3 level (g/L) | low | low | normal | normal |
C4 level (g/L) | normal | normal | normal | normal |
CH50 (%) | low | low | normal | normal |
Antinuclear antibodies | negative | negative | NA | negative |
ANCA | NA | negative | NA | NA |
Cryoglobulinemia | mixed 2a | mixed 2b | mixed 2 | NA |
VHC antibodies | negative | negative | negative | NA |
PVB19 IgG antibodies | positive | positive | positive | positive |
PVB19 IgM antibodies | positive | positive | positive | positive |
PVB19 PCR: blood | positive | positive | positive | negative |
PVB19 PCR: renal tissue | NA | positive | NA | negative |
Kidney Biopsy | Membrano-proliferative GN, full-house pattern | Minimal change disease and acute tubular necrosis | NA | Membrano-proliferative GN, C3 deposits |