The correlation analysis between the Oxford classification of Chinese IgA nephropathy children and renal outcome - a retrospective cohort study

Table 5 Factors at biopsy influencing renal outcome from ESRD or 50% drop in eGFR by univariate and multivariate Cox regression

Risk factors	Univariate Cox Regression	Multivariate Cox Regression
	HR(95%CI)	HR(95%CI)
Mesangial hypercellularity
M0	1
M1	1.8 (1.3 ~ 2.3)
P-value	0.115
Endocapillary hypercellularity
E0	1
E1	1.4 (0.9 ~ 2.1)
P-value	0.326
Segmental glomerulosclerosis
S0	1	1
S1	3.5 (2.3 ~ 5.3)	2.7 (1.8 ~ 4.2)
P-value	<0.001	<0.001
Tubular atrophy/interstitial fibrosis
T0	1	1
T1 or T2	2.6 (2.1 ~ 3.3)	6.6 (3.9 ~ 11.3)
P-value	<0.001	<0.001
Crescent
C0	1	1
C1 or C2	2.1 (1.5 ~ 2.8)	1.8 (1.2 ~ 2.5)
P-value	<0.001	0.212

Univariate Cox Regression model: unadjusted. Multivariate Cox Regression model: adjusted for initial eGFR, initial mean arterial pressure, and initial proteinuria
Abbreviations: CI Confidence interval, HR Hazard ratio, M0 Mesangial hypercellularity≤0.5, M1 Mesangial hypercellularity>0.5, E0 Absence of endocapillary hypercellularity, E1 Presence of endocapillary hypercellularity, S0 Absence of segmental glomerulosclerosis, S1 Presence of segmental glomerulosclerosis, T0 Tubular atrophy/ interstitial fibrosis 0–25% of cortical area, T1 Tubular atrophy/ interstitial fibrosis 26–50% of cortical area, T2 Tubular atrophy/interstitial fibrosis≥50% of cortical area, C0 Absence of crescents, C1 Crescents in at least one but < 25% of glomeruli, C2 Crescents in more than 25% of glomeruli

ISSN: 1471-2369