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Table 5 Factors at biopsy influencing renal outcome from ESRD or 50% drop in eGFR by univariate and multivariate Cox regression

From: The correlation analysis between the Oxford classification of Chinese IgA nephropathy children and renal outcome - a retrospective cohort study

Risk factors Univariate Cox Regression Multivariate Cox Regression
  HR(95%CI) HR(95%CI)
Mesangial hypercellularity
 M0 1  
 M1 1.8 (1.3 ~ 2.3)  
P-value 0.115  
Endocapillary hypercellularity
 E0 1  
 E1 1.4 (0.9 ~ 2.1)  
P-value 0.326  
Segmental glomerulosclerosis
 S0 1 1
 S1 3.5 (2.3 ~ 5.3) 2.7 (1.8 ~ 4.2)
P-value <0.001 <0.001
Tubular atrophy/interstitial fibrosis
 T0 1 1
 T1 or T2 2.6 (2.1 ~ 3.3) 6.6 (3.9 ~ 11.3)
P-value <0.001 <0.001
Crescent
 C0 1 1
 C1 or C2 2.1 (1.5 ~ 2.8) 1.8 (1.2 ~ 2.5)
P-value <0.001 0.212
  1. Univariate Cox Regression model: unadjusted. Multivariate Cox Regression model: adjusted for initial eGFR, initial mean arterial pressure, and initial proteinuria
  2. Abbreviations: CI Confidence interval, HR Hazard ratio, M0 Mesangial hypercellularity≤0.5, M1 Mesangial hypercellularity>0.5, E0 Absence of endocapillary hypercellularity, E1 Presence of endocapillary hypercellularity, S0 Absence of segmental glomerulosclerosis, S1 Presence of segmental glomerulosclerosis, T0 Tubular atrophy/ interstitial fibrosis 0–25% of cortical area, T1 Tubular atrophy/ interstitial fibrosis 26–50% of cortical area, T2 Tubular atrophy/interstitial fibrosis≥50% of cortical area, C0 Absence of crescents, C1 Crescents in at least one but < 25% of glomeruli, C2 Crescents in more than 25% of glomeruli