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Table 1 Baseline characteristics of patients with early and delayed lupus nephritis

From: Comparison of clinical features and outcomes between patients with early and delayed lupus nephritis

Variables

Total (nā€‰=ā€‰171)

Patients with early lupus nephritis (nā€‰=ā€‰106)

Patients with delayed lupus nephritis (nā€‰=ā€‰65)

p-value

Demographic data

ā€ƒAge, years

36.0 (26.3ā€“46.0)

36.0 (25.0ā€“48.0)

36.0 (29.0ā€“44.0)

0.903

ā€ƒFemale sex, n (%)

153 (89.5)

91 (85.8)

62 (95.4)

0.070

ā€ƒDisease duration, months

n/a

n/a

52.6 (22.0ā€“118.8)

<ā€‰0.001

ā€ƒFollow-up duration, months

57.1 (17.5ā€“90.8)

40.9 (14.2ā€“91.3)

67.6 (27.0ā€“88.9)

0.119

SLE specific variables

ā€ƒNon-renal SLEDAI-2ā€‰K

5.0 (4.0ā€“7.0)

6.0 (5.0ā€“8.0)

4.0 (4.0ā€“6.0)

<ā€‰0.001

ā€ƒComplement 3, mg/dL

42.7 (28.7ā€“66.4)

40.3 (26.2ā€“67.3)

46.4 (34.9ā€“64.5)

0.129

ā€ƒLow complement 3, n (%)

154 (90.1)

95 (89.6)

59 (90.8)

0.808

ā€ƒComplement 4, mg/dL

5.6 (3.0ā€“12.5)

5.3 (3.0ā€“12.5)

6.2 (3.5ā€“12.3)

0.623

ā€ƒLow complement 4, n (%)

114 (66.7)

73 (68.9)

41 (63.1)

0.437

ā€ƒAnti-dsDNA (IU/mL)

218.4 (32.3ā€“379.0)

160.0 (10.0ā€“379.0)

300.0 (143.3ā€“379.0)

0.009

ā€ƒElevated anti-dsDNA, n (%)

141 (82.5)

83 (78.3)

58 (89.2)

0.069

ā€ƒSpot urine P/Cr ratio

2.9 (1.5ā€“6.0)

3.4 (1.5ā€“6.5)

2.3 (1.5ā€“4.2)

0.123

Laboratory data

ā€ƒWBC count (/Ī¼L)

4400.0 (3147.5ā€“6145.0)

3925.0 (3030.5630.0)

4950.0 (3947.5ā€“6727.5)

0.018

ā€ƒPlatelet count (Ɨā€‰1000/Ī¼L)

203.0 (136.3ā€“247.8)

200.0 (113.0ā€“240.0)

213.0 (152.8ā€“253.3)

0.126

ā€ƒHemoglobin (g/dL)

10.4 (9.1ā€“11.7)

10.2 (8.9ā€“11.5)

10.9 (9.5ā€“11.9)

0.189

ā€ƒLymphocyte count (/Ī¼L)

860.0 (580.0ā€“1227.5)

840.0 (550.0ā€“1250.0)

900.0 (610.-1222.5)

0.999

ā€ƒESR (mm/hr)

53.0 (28.5ā€“76.0)

57.0 (35.0ā€“84.0)

41.0 (24.8ā€“68.8)

0.013

ā€ƒCRP (mg/L)

2.5 (1.0ā€“8.9)

3.0 (1.0ā€“9.6)

1.9 (1.0ā€“4.9)

0.074

ā€ƒCr (mg/dL)

0.8 (0.6ā€“1.1)

0.8 (0.6ā€“1.1)

0.8 (0.6ā€“1.0)

0.434

ā€ƒAlbumin (g/dL)

2.9 (2.2ā€“3.4)

2.6 (2.1ā€“3.3)

3.2 (2.6ā€“3.4)

0.002

Clinical manifestations

ā€ƒSkin rash

53 (31.0)

41 (38.7)

12 (18.5)

0.006

ā€ƒPhotosensitivity

13 (7.6)

10 (9.4)

3 (4.6)

0.374

ā€ƒOral ulcer

21 (12.3)

19 (17.9)

2 (3.1)

0.004

ā€ƒArthritis

10 (5.8)

8 (7.5)

2 (3.1)

0.322

ā€ƒSerositis

41 (24.0)

35 (33.0)

6 (9.2)

<ā€‰0.001

ā€ƒNeurologic disorder

2 (1.2)

1 (0.9)

1 (1.5)

0.726

ā€ƒHematologic disorder

152 (88.9)

95 (89.6)

57 (87.7)

0.698

ā€ƒImmunologic disorder

159 (93.0)

100 (94.3)

59 (90.8)

0.376

Comorbidities

ā€ƒHypertension

33 (19.3)

11 (10.4)

22 (33.8)

<ā€‰0.001

ā€ƒDiabetes mellitus

4 (2.3)

3 (2.8)

1 (1.5)

0.999

ā€ƒDyslipidemia

2 (1.2)

2 (1.9)

0 (0.0)

0.526

  1. Values are expressed as median (interquartile range) or n (%)
  2. n/a not applicable, SLEDAI-2ā€‰K systemic lupus erythematosus disease activity index-2000, P/Cr protein/creatinine, WBC white blood cell, ESR erythrocyte sedimentation rate, CRP C-reactive protein, Cr creatinine