Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis

Imani, Danyal; Razi, Bahman; Khosrojerdi, Arezou; Lorian, Kaivan; Motallebnezhad, Morteza; Rezaei, Ramazan; Aslani, Saeed

doi:10.1186/s12882-020-01919-1

BMC Nephrology

Table 2 Distribution of genotype and allele among urolithiasis patients and controls

From: Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis

Study author	Urolithiasis cases					Healthy control					P-HWE	MAF
Study author	FF	Ff	ff	F	F	FF	Ff	ff	F	f	P-HWE	MAF
FokI (rs2228570)
Chen et al. (b)	54	67	25	175	117	21	43	26	85	95	0/43	0/527
Shaogang et al.	27	64	59	118	182	17	44	19	78	82	0/36	0/512
Rendina et al.	69	68	22	206	112	53	55	16	161	87	0/77	0/350
Mossetti et al.	43	47	20	133	87	53	55	19	161	93	0/45	0/366
Relan et al.	25	72	53	122	178	38	36	26	112	88	0/01	0/44
Bid et al. (a)	30	106	2	136	90	77	84	5	238	94	0/02	0/257
Bid et al. (b)	11	38	1	60	40	30	28	2	88	32	0/13	0/266
Liu et al.	64	113	58	241	229	58	116	57	232	230	0/94	0/497
Seo et al.	84	134	60	302	254	155	288	92	598	472	0/03	0/441
Mittal et al.	25	98	2	214	86	69	76	5	148	102	< 0.01	0/408
Basiri et al.	54	42	6	150	54	36	27	43	99	113	< 0.01	0/533
Kaysar et al.	19	43	12	81	67	33	39	31	105	101	0/01	0/490
Wang et al.	150	234	80	534	394	125	226	99	476	424	0/86	0/471
Guha et al.	78	115	7	271	129	98	90	12	286	114	0/74	0/542
Cakir et al.	48	38	12	134	62	39	25	6	103	37	0/39	0/618
Ergon et al.	14	12	1	40	14	7	6	0	20	6	0/27	0/230
Subasi et al.	23	25	4	71	33	26	21	4	73	29	0/93	0/284
Li et al.	38	102	60	178	222	31	72	17	134	106	0/02	0/4416
Huang et al.	73	49	8	195	65	104	96	24	304	144	0/79	0/321
Amar et al.	136	79	11	351	101	146	77	10	369	97	0.37	0.519
Study author	Urolithiasis cases					Healthy control					P-HWE	MAF
Study author	TT	Tt	tt	T	t	TT	Tt	tt	T	t	P-HWE	MAF
TaqI (rs731236)
Jackman et al.	6	7	4	19	15	17	8	12	42	32	0/82	0/432
Nishijima et al.	49	30	4	128	38	60	22	1	142	24	0/1	0/228
Ozkaya et al.	33	27	4	93	35	50	30	10	130	50	0/81	0/277
Mossetti et al.	80	104	36	264	176	35	66	13	136	92	0/53	0/719
Shaogang et al.	52	74	24	178	122	33	36	11	102	58	0/3	0/362
Mossetti et al.	21	53	36	95	125	21	68	38	110	144	0/39	0/566
Gunes et al.	37	63	10	137	83	61	73	16	195	105	0/02	0/35
Shayan et al.	27	35	18	89	71	13	25	2	51	29	0/74	0/362
Moyano et al.	15	23	13	53	49	9	10	2	28	14	< 0.01	0/333
Seo et al.	252	23	3	527	29	487	39	7	1013	53	0/05	0/049
Mittal et al.	56	61	8	173	77	84	50	16	218	82	0/03	0/273
Basiri et al.	41	50	11	132	72	52	37	17	141	71	0/77	0/334
Wang et al.	430	32	2	892	36	414	35	1	863	37	0/08	0/041
Aykan et al.	67	61	36	195	133	66	86	15	218	116	< 0.01	0/347
Guha et al.	58	82	60	196	202	65	58	77	188	212	0/67	0/349
Rendina et al.	186	158	28	530	214	31	44	13	106	70	0/16	0/473
Cakir et al.	35	44	19	114	82	31	29	10	91	49	0/43	0/173
Goknar et al.	25	41	12	91	65	14	43	3	71	49	0/83	0/408
Subasi et al.	4	25	23	33	71	9	24	18	42	60	0/77	0/588
Li et al.	189	11	0	389	11	114	6	0	234	6	0/82	0/025
Yang et al.	849	92	2	1790	96	870	103	2	1843	107	0/67	0/471
Amar et al.	112	86	29	310	144	116	104	23	336	150	0/42	0/149
Study author	Urolithiasis cases					Healthy control					P-HWE	MAF
Study author	BB	Bb	bb	B	b	BB	Bb	bb	B	b	P-HWE	MAF
BsmI (rs1544410)
Ruggiero et al.	4	12	11	19	35	18	108	24	144	156	< 0.01	0/52
Chen et al. (a)	110	10	4	230	18	78	9	3	165	15	< 0.01	0/083
Ozkaya et al.	5	36	23	46	82	13	49	28	75	105	0/25	0/583
Rendina et al.	47	69	43	163	155	39	56	29	134	114	0/31	0/459
Mossetti et al.	40	46	24	126	94	40	56	31	136	118	0/2	0/464
Relan et al.	48	62	40	158	142	46	28	26	120	80	< 0.01	0/40
Gunes et al.	15	64	31	94	126	19	75	56	113	187	0/42	0/623
Moyano et al.	5	25	21	35	67	5	9	7	19	23	0/53	0/547
Wang et al.	3	66	395	72	856	2	70	378	74	826	0/51	0/917
Cakir et al.	43	40	15	126	70	26	34	10	86	54	0/57	0/476
Goknar et al.	21	35	16	77	67	16	37	0	69	37	0/01	0/349
Subasi et al.	28	19	5	75	29	20	23	8	63	39	0/74	0/382
Li et al.	181	19	0	381	19	111	9	0	231	9	0/67	0/0375
Yang et al.	65	394	484	524	1362	78	417	480	573	1377	0/28	0/315
Study author	Urolithiasis cases					Healthy control					P-HWE	MAF
Study author	AA	Aa	aa	A	a	AA	Aa	aa	A	a	P-HWE	MAF
ApaI (rs7975232)
Nishijima et al.	14	34	35	62	104	9	37	37	55	111	0/25	0/626
Shaogang et al.	32	69	49	133	167	11	38	31	60	100	0/9	0/625
Ozkaya et al.	13	30	21	56	72	4	50	36	58	122	0/09	0/677
Rendina et al.	43	87	29	173	145	37	68	19	142	106	0/18	0/427
Gunes et al.	40	58	12	138	82	59	72	19	190	110	0/68	0/366
Moyano et al.	11	29	11	51	51	7	9	5	23	19	0/53	0/452
Seo et al.	152	84	37	388	158	282	192	51	756	294	0/03	0/28
Mittal et al.	43	70	12	156	94	57	71	22	185	115	0/98	0/383
Kaysar et al..	21	29	24	71	77	32	42	29	106	100	0/06	0/485
Wang et al	27	177	259	231	695	46	195	209	287	613	0/75	0/748
Cakir et al.	43	40	15	126	70	26	34	10	86	54	0/63	0/135
Goknar et al.	24	42	12	90	66	11	40	9	62	58	0/01	0/483
Ergon et al.	9	12	6	30	24	4	6	3	14	12	0/79	0/461
Subasi et al.	18	24	10	60	44	22	14	15	58	44	0/01	0/431
Li et al.	73	87	40	233	167	57	51	12	165	75	0/9	0/312
Yang et al.	65	394	484	524	1362	78	417	480	573	1377	0/49	0/743

Abbreviations: P-HWE p-value for Hardy–Weinberg equilibrium, MAF minor allele frequency of control group

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