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Table 3 Main results of pooled ORs in meta-analysis of VDR gene polymorphisms

From: Vitamin D receptor gene polymorphisms and susceptibility to urolithiasis: a meta-regression and meta-analysis

Subgroup   Sample size Test of association Test of heterogeneity Test of publication bias (Begg’s test) Test of publication bias (Egger’s test)
  Genetic model Case/Control OR 95%CI (p-value) I2 (%) P Z P T P
FokI (rs2228570)
Overall Dominant model 3114 / 3174 1.16 0.90–1.50(0.25) 77.7 ≤0.001 1.73 0.08 1.37 0.19
Recessive model 3114 / 3174 0.92 0.68–1.25(0.58) 67.2 ≤0.001 −1.17 0.24 −0.68 0.50
Allelic model 3114 / 3174 1.02 0.86–1.22(0.82) 78.5 ≤0.001 0.25 0.80 0.45 0.66
ff vs. FF 3114 / 3174 1.10 0.72–1.69(0.65) 77.9 ≤0.001 −0.72 0.47 −0.14 0.88
Ff vs. FF 3114 / 3174 1.12 0.88–1.43(0.34) 74.1 ≤0.001 1.94 0.05 1.39 0.18
East-Asian Dominant model 1677 / 1833 0.91 0.77–1.06(0.22) 1 0.42 0.99 0.32 1.64 0.15
Recessive model 1677 / 1833 0.98 0.66–1.45(0.91) 74.9 ≤0.001 0 1 −0.18 0.86
Allelic model 1677 / 1833 0.95 0.78–1.16(0.62) 71.6 ≤0.001 −0.25 0.80 0.15 0.88
ff vs. FF 1677 / 1833 0.93 0.61–1.40(0.71) 67.7 ≤0.001 0 1 0.10 0.92
Ff vs. FF 1677 / 1833 0.88 0.74–1.04(0.12) 0 0.48 0.78 0.45 0.84 0.43
Caucasian Dominant model 1437 / 1341 1.33 0.87–2.05(0.18) 83.6 ≤0.001 1.04 0.29 0.62 0.55
Recessive model 1437 / 1341 0.84 0.49–1.44(0.52) 62.8 ≤0.001 −1.73 0.08 −0.69 0.51
Allelic model 1437 / 1341 1.08 0.81–1.45(0.59) 82.1 ≤0.001 −0.21 0.83 0.2 0.82
ff vs. FF 1437 / 1341 1.28 0.56–2.94(0.55) 81 ≤0.001 −0.25 0.80 −0.68 0.52
Ff vs. FF 1437 / 1341 1.33 0.90–1.98(0.15) 75.5 ≤0.001 1.25 0.21 0.56 0.59
TaqI (rs731236)
Overall Dominant model 4188 / 3955 1.05 0.93–1.19(0.41) 14 0.27 0.45 0.65 0.40 0.69
Recessive model 4188 / 3955 1.07 0.88–1.30(0.48) 31.5 0.08 0.05 0.96 −0.23 0.83
Allelic model 4188 / 3955 1.06 0.97–1.16(0.23) 2.6 0.42 −0.18 0.85 −0.21 0. 83
tt vs. TT 4188 / 3955 1.27 1.01–1.59(0.04) 0 0.68 0.05 0.96 −0.06 0.95
Tt vs. TT 4188 / 3955 1.04 0.91–1.18(0.59) 34.5 0.05 0.45 0.65 0.33 0.74
East-Asian Dominant model 2118/ 2241 0.94 0.76–1.16(0.55) 0 0.56 0.19 0.85 −0.19 0.85
Recessive model 2118/ 2241 0.97 0.50–1.88(0.92) 0 0.68 −0.49 0.62 −1.45 0.24
Allelic model 2118/ 2241 0.95 0.79–1.15(0.60) 0 0.51 −1.69 0.09 −1.27 0.27
tt vs. TT 2118/ 2241 1.02 0.51–2.02(0.96) 0 0.50 −0.98 0.32 −1.70 0.18
Tt vs. TT 2118/ 2241 0.94 0.76–1.16(0.26) 0 0.67 0.56 0.57 0.37 0.73
Caucasian Dominant model 2070 / 1714 1.12 0.96–1.29(0.15) 20.3 0.22 0.09 0.92 −0.03 0.97
Recessive model 2070 / 1714 1.08 0.88–1.33(0.44) 44.1 0.03 1.16 0.24 0.92 0.38
Allelic model 2070 / 1714 1.09 0.98–1.21(0.09) 4.5 0.40 1.34 0.18 1.58 0.15
tt vs. TT 2070 / 1714 1.30 1.02–1.65(0.03) 0 0.62 1.52 0.12 2.35 0.04
Tt vs. TT 2070 / 1714 1.10 0.93–1.29(0.56) 45.7 0.02 −0.80 0.42 −0.41 0.69
BsmI (rs1544410)
Overall Dominant model 3065/2915 0.97 0.84–1.12(0.69) 12 0.31 0.41 0.68 - 0.04 0.96
Recessive model 3065/2915 0.98 0.86–1.12(0.74) 38.7 0.06 0.27 0.78 0.46 0.65
Allelic model 3065/2915 0.99 0.91–1.08(0.82) 42.5 0.03 0.55 0.58 0.74 0.47
bb vs. BB 3065/2915 0.95 0.79–1.14(0.56) 22.2 0.21 0.27 0.78 0.10 0.92
Bb vs. BB 3065/2915 0.97 0.83–1.14(0.74) 0.8 0.44 0 1 0.38 0.71
East-Asian Dominant model 1783 / 1686 0.86 0.71–1.05(0.41) 0 0.76 0.52 0.60 −0.47 0.72
Recessive model 1783 / 1686 0.88 0.73–1.05(0.16) 0 0.59 −1.00 0.31
Allelic model 1783 / 1686 0.89 0.79–1.01(0.06) 0 0.58 0.52 0.60 −0.04 0.97
bb vs. BB 1783 / 1686 0.78 0.60–1.00(0.05) 0 0.88 −1.00 0.31
Bb vs. BB 1783 / 1686 0.91 0.73–1.12(0.36) 0 0.81 −0.52 0.60 0.87 0.54
Caucasian Dominant model 1282/ 1229 1.11 0.90–1.36(0.34) 18.6 0.26 0 1 0.22 0.83
Recessive model 1282/ 1229 1.11 0.91–1.35(0.30) 45.3 0.05 0.49 0.62 0.81 0.45
Allelic model 1282/ 1229 1.10 0.97–1.24(0.12) 43.2 0.06 0.83 0.40 0.92 0.38
bb vs. BB 1282/ 1229 1.16 0.89–1.50(0.26) 21.5 0.24 0.99 0.32 0.47 0.65
Bb vs. BB 1282/ 1229 1.06 0.84–1.32(0.63) 20.7 0.24 - 0. 21 0.83 - 0.09 0.93
ApaI (rs7975232)
Overall Dominant model 2950 / 3065 1.08 0.93–1.25(0.30) 48.6 0.01 - 0.35 0.72 - 0.54 0.60
Recessive model 2950 / 3065 1.14 1.01–1.29(0.03) 3.5 0.41 - 0.38 0.70 - 0.02 0.98
Allelic model 2950 / 3065 1.09 1.00–1.18(0.05) 31 0.11 - 0.64 0.52 0..42 0.67
aa vs. AA 2950 / 3065 1.21 1.00–1.47(0.05) 27.5 0.14 - 1.15 0.25 - 0.85 0.41
Aa vs. AA 2950 / 3065 1.10 0.94–1.28(0.29) 41.1 0.04 - 0.94 0.34 - 0.39 0.70
East-Asian Dominant model 2186/ 2336 1.15 0.96–1.38(0.12) 38.8 0.13 0.19 0.85 0.21 0.84
Recessive model 2186/ 2336 1.20 1.05–1.37(≤0.001) 32 0.18 1.69 0.09 1.37 0.24
Allelic model 2186/ 2336 1.15 1.05–1.26(≤0.001) 49.1 0.06 0.19 0.85 - 0.09 0.93
aa vs. AA 2186/ 2336 1.40 1.12–1.75(≤0.001) 36.1 0.15 - 0.19 0.85 0.45 0.67
Aa vs. AA 2186/ 2336 1.10 0.90–1.33(0.35) 40.7 0.12 0.56 0.57 0.54 0.62
Caucasian Dominant model 764 / 729 0.96 0.75–1.22(0.73) 55.4 0.02 - 0.83 0.40 - 1.14 0.29
Recessive model 764 / 729 0.86 0.64–1.17(0.34) 0 0.94 0.49 0.62 - 0.25 0.81
Allelic model 764 / 729 0.94 0.80–1.09(0.40) 0 0.75 0.42 0.67 0.60 0.56
aa vs. AA 764 / 729 0.83 0.58–1.20(0.32) 0 0.68 - 0.99 0.32 - 1.32 0.23
Aa vs. AA 764 / 729 1.10 0.85–1.42(0.45) 47.9 0.05 - 1.25 0.21 - 1.40 0.20