Table 3 Main results of pooled ORs in meta-analysis of VDR gene polymorphisms

Overall

Dominant model

3114 / 3174

1.16

0.90–1.50(0.25)

77.7

≤0.001

1.73

0.08

1.37

0.19

Recessive model

3114 / 3174

0.92

0.68–1.25(0.58)

67.2

≤0.001

−1.17

0.24

−0.68

0.50

Allelic model

3114 / 3174

1.02

0.86–1.22(0.82)

78.5

≤0.001

0.25

0.80

0.45

0.66

ff vs. FF

3114 / 3174

1.10

0.72–1.69(0.65)

77.9

≤0.001

−0.72

0.47

−0.14

0.88

Ff vs. FF

3114 / 3174

1.12

0.88–1.43(0.34)

74.1

≤0.001

1.94

0.05

1.39

0.18

East-Asian

Dominant model

1677 / 1833

0.91

0.77–1.06(0.22)

1

0.42

0.99

0.32

1.64

0.15

Recessive model

1677 / 1833

0.98

0.66–1.45(0.91)

74.9

≤0.001

0

1

−0.18

0.86

Allelic model

1677 / 1833

0.95

0.78–1.16(0.62)

71.6

≤0.001

−0.25

0.80

0.15

0.88

ff vs. FF

1677 / 1833

0.93

0.61–1.40(0.71)

67.7

≤0.001

0

1

0.10

0.92

Ff vs. FF

1677 / 1833

0.88

0.74–1.04(0.12)

0

0.48

0.78

0.45

0.84

0.43

Caucasian

Dominant model

1437 / 1341

1.33

0.87–2.05(0.18)

83.6

≤0.001

1.04

0.29

0.62

0.55

Recessive model

1437 / 1341

0.84

0.49–1.44(0.52)

62.8

≤0.001

−1.73

0.08

−0.69

0.51

Allelic model

1437 / 1341

1.08

0.81–1.45(0.59)

82.1

≤0.001

−0.21

0.83

0.2

0.82

ff vs. FF

1437 / 1341

1.28

0.56–2.94(0.55)

81

≤0.001

−0.25

0.80

−0.68

0.52

Ff vs. FF

1437 / 1341

1.33

0.90–1.98(0.15)

75.5

≤0.001

1.25

0.21

0.56

0.59

Overall

Dominant model

4188 / 3955

1.05

0.93–1.19(0.41)

14

0.27

0.45

0.65

0.40

0.69

Recessive model

4188 / 3955

1.07

0.88–1.30(0.48)

31.5

0.08

0.05

0.96

−0.23

0.83

Allelic model

4188 / 3955

1.06

0.97–1.16(0.23)

2.6

0.42

−0.18

0.85

−0.21

0. 83

tt vs. TT

4188 / 3955

1.27

1.01–1.59(0.04)

0

0.68

0.05

0.96

−0.06

0.95

Tt vs. TT

4188 / 3955

1.04

0.91–1.18(0.59)

34.5

0.05

0.45

0.65

0.33

0.74

East-Asian

Dominant model

2118/ 2241

0.94

0.76–1.16(0.55)

0

0.56

0.19

0.85

−0.19

0.85

Recessive model

2118/ 2241

0.97

0.50–1.88(0.92)

0

0.68

−0.49

0.62

−1.45

0.24

Allelic model

2118/ 2241

0.95

0.79–1.15(0.60)

0

0.51

−1.69

0.09

−1.27

0.27

tt vs. TT

2118/ 2241

1.02

0.51–2.02(0.96)

0

0.50

−0.98

0.32

−1.70

0.18

Tt vs. TT

2118/ 2241

0.94

0.76–1.16(0.26)

0

0.67

0.56

0.57

0.37

0.73

Caucasian

Dominant model

2070 / 1714

1.12

0.96–1.29(0.15)

20.3

0.22

0.09

0.92

−0.03

0.97

Recessive model

2070 / 1714

1.08

0.88–1.33(0.44)

44.1

0.03

1.16

0.24

0.92

0.38

Allelic model

2070 / 1714

1.09

0.98–1.21(0.09)

4.5

0.40

1.34

0.18

1.58

0.15

tt vs. TT

2070 / 1714

1.30

1.02–1.65(0.03)

0

0.62

1.52

0.12

2.35

0.04

Tt vs. TT

2070 / 1714

1.10

0.93–1.29(0.56)

45.7

0.02

−0.80

0.42

−0.41

0.69

Overall

Dominant model

3065/2915

0.97

0.84–1.12(0.69)

12

0.31

0.41

0.68

- 0.04

0.96

Recessive model

3065/2915

0.98

0.86–1.12(0.74)

38.7

0.06

0.27

0.78

0.46

0.65

Allelic model

3065/2915

0.99

0.91–1.08(0.82)

42.5

0.03

0.55

0.58

0.74

0.47

bb vs. BB

3065/2915

0.95

0.79–1.14(0.56)

22.2

0.21

0.27

0.78

0.10

0.92

Bb vs. BB

3065/2915

0.97

0.83–1.14(0.74)

0.8

0.44

0

1

0.38

0.71

East-Asian

Dominant model

1783 / 1686

0.86

0.71–1.05(0.41)

0

0.76

0.52

0.60

−0.47

0.72

Recessive model

1783 / 1686

0.88

0.73–1.05(0.16)

0

0.59

−1.00

0.31

–

–

Allelic model

1783 / 1686

0.89

0.79–1.01(0.06)

0

0.58

0.52

0.60

−0.04

0.97

bb vs. BB

1783 / 1686

0.78

0.60–1.00(0.05)

0

0.88

−1.00

0.31

–

–

Bb vs. BB

1783 / 1686

0.91

0.73–1.12(0.36)

0

0.81

−0.52

0.60

0.87

0.54

Caucasian

Dominant model

1282/ 1229

1.11

0.90–1.36(0.34)

18.6

0.26

0

1

0.22

0.83

Recessive model

1282/ 1229

1.11

0.91–1.35(0.30)

45.3

0.05

0.49

0.62

0.81

0.45

Allelic model

1282/ 1229

1.10

0.97–1.24(0.12)

43.2

0.06

0.83

0.40

0.92

0.38

bb vs. BB

1282/ 1229

1.16

0.89–1.50(0.26)

21.5

0.24

0.99

0.32

0.47

0.65

Bb vs. BB

1282/ 1229

1.06

0.84–1.32(0.63)

20.7

0.24

- 0. 21

0.83

- 0.09

0.93

Overall

Dominant model

2950 / 3065

1.08

0.93–1.25(0.30)

48.6

0.01

- 0.35

0.72

- 0.54

0.60

Recessive model

2950 / 3065

1.14

1.01–1.29(0.03)

3.5

0.41

- 0.38

0.70

- 0.02

0.98

Allelic model

2950 / 3065

1.09

1.00–1.18(0.05)

31

0.11

- 0.64

0.52

0..42

0.67

aa vs. AA

2950 / 3065

1.21

1.00–1.47(0.05)

27.5

0.14

- 1.15

0.25

- 0.85

0.41

Aa vs. AA

2950 / 3065

1.10

0.94–1.28(0.29)

41.1

0.04

- 0.94

0.34

- 0.39

0.70

East-Asian

Dominant model

2186/ 2336

1.15

0.96–1.38(0.12)

38.8

0.13

0.19

0.85

0.21

0.84

Recessive model

2186/ 2336

1.20

1.05–1.37(≤0.001)

32

0.18

1.69

0.09

1.37

0.24

Allelic model

2186/ 2336

1.15

1.05–1.26(≤0.001)

49.1

0.06

0.19

0.85

- 0.09

0.93

aa vs. AA

2186/ 2336

1.40

1.12–1.75(≤0.001)

36.1

0.15

- 0.19

0.85

0.45

0.67

Aa vs. AA

2186/ 2336

1.10

0.90–1.33(0.35)

40.7

0.12

0.56

0.57

0.54

0.62

Caucasian

Dominant model

764 / 729

0.96

0.75–1.22(0.73)

55.4

0.02

- 0.83

0.40

- 1.14

0.29

Recessive model

764 / 729

0.86

0.64–1.17(0.34)

0

0.94

0.49

0.62

- 0.25

0.81

Allelic model

764 / 729

0.94

0.80–1.09(0.40)

0

0.75

0.42

0.67

0.60

0.56

aa vs. AA

764 / 729

0.83

0.58–1.20(0.32)

0

0.68

- 0.99

0.32

- 1.32

0.23

Aa vs. AA

764 / 729

1.10

0.85–1.42(0.45)

47.9

0.05

- 1.25

0.21

- 1.40

0.20