Table 2 values of percentages and absolute numbers of T cell subset during aging
From: Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients
ALL | Aged 20–45 | Aged 46–59 | Aged 60–69 | Aged 70–79 | Aged 80–89 | P value | |
|---|---|---|---|---|---|---|---|
N = 446 | N = 84 | N = 128 | N = 129 | N = 63 | N = 42 | ||
Cell subset percentage | |||||||
CD4+T cells %* | 57.1(49.6,64.6) | 55.5(49.2,60.4) | 58.2 (52.3,67.0) | 57.9(50.4,65.8) | 54.6(47.6,63.2) | 56.2(48.3,67.0) | 0.02 |
CD4+ TNAIVE %* | 36.7(26.2,46.8) | 43.5(34.0,53.1) | 37.1(26.5,48.3) | 34.9(26.2,45.5) | 29.5(20.7,44.9) | 32.9(20.1,45.3) | < 0.001 |
CD4+TCM%* | 21.7(15.1,28.7) | 17.0(12.4,25.7) | 21.3(15.2,25.9) | 23.5(15.4,31.2) | 23.1(18.5,31.4) | 22.6(15.3,29.4) | 0.002 |
CD4+TEM%* | 33.2(25.4,42.3) | 28.7(22.3,34.8) | 32.8(25.4,42.0) | 35.1(25.2,43.3) | 37.9(26.2,45.6) | 36.1(26.1,45.6) | < 0.001 |
CD4+TEMRA% | 4.2(2.5,7.6) | 4.8(2.8,8.9) | 4.9(2.8,7.5) | 4.3(2.5,7.9) | 3.4(2.2,6.3) | 3.6(2.0,6.2) | 0.932 |
CD8+T cells %* | 34.6(28.5,41.3) | 36.2(32.3,42.1) | 32.7(26.9,40.3) | 33.2(26.8,39.4) | 36.1(30.3,46.3) | 36.0(27.5,43.9) | 0.003 |
CD8+ TNAIVE % * | 19.9(12.2,30.3) | 37.1(28.4,52.5) | 22.7(16.5,33.1) | 15.5(13.0,24.9) | 10.5(7.2,17.7) | 9.5(5.3,15.4) | < 0.001 |
CD8+ TCM%* | 2.8(1.7,4.5) | 2.1(1.4,2.9) | 2.7(1.7,4.3) | 3.5(2.0,4.9) | 3.1(1.7,4.9) | 3.1(1.7,5.3) | 0.001 |
CD8 +TEM%* | 22.5(15.5,30.9) | 17.3(12.6,23.1) | 22.0(16.1,30.2) | 25.5(16.0,33.0) | 27.1(17.2,36.2) | 24.7(16.2,38.4) | < 0.001 |
CD8+TEMRA%* | 49.7(37.0,60.3) | 40.1(27.9,50.0) | 48.1(34.1,58.1) | 52.2(39.7,59.9) | 57.9(43.3,69.8) | 63.1(45.8,70.4) | < 0.001 |
CD4+Tcell /CD8+ T cell | 1.64(1.21,2.25) | 1.50(1.18,1.88) | 1.76(1.31,2.49) | 1.73(1.31,2.54) | 1.56(1.01,2.02) | 1.52(1.10,2.43) | 0.051 |
Absolute cell number | |||||||
CD4+T cells (cells/μl)* | 387(291,548) | 500(367,636) | 428(326,549) | 369(279,524) | 352(211,447) | 345(264,411) | < 0.001 |
CD4+ TNAIVE (cells/μl)* | 135(81,224) | 226(148,292) | 151(86,232) | 124(84,186) | 101(41,147) | 104(56,175) | < 0.001 |
CD4+TCM (cells/μl) | 85(54,126) | 86(50,140) | 84(55,125) | 88(55,125) | 79(54,130) | 80(47,112) | 0.324 |
CD4+TEM (cells/μl) | 129(86,187) | 136(91,189) | 139(88,190) | 127(89,180) | 115(83,172) | 108(78,197) | 0.487 |
CD4+TEMRA (cells/μl)* | 18(10,32) | 25(11,46) | 20(10,36) | 16(10,28) | 13(6,28) | 13(7,20) | 0.005 |
CD8+T cells (cells/μl)* | 236(162,355) | 318(251,448) | 226(163,353) | 209(138,315) | 217(159,326) | 219(139,321) | < 0.001 |
CD8+ TNAIVE (cells/μl)* | 44(23,83) | 129(85,164) | 54(35,83) | 37(21,62) | 25(16,38) | 20(13,30) | < 0.001 |
CD8+ TCM (cells/μl) | 5(3,8) | 5(3,7) | 5(3,8) | 6(3,9) | 6(3,10) | 5(3,9) | 0.363 |
CD8 +TEM (cells/μl) | 41(28,61) | 41(32,53) | 39(27,62) | 41(26,63) | 46(28,71) | 39(29,64) | 0.28 |
CD8+TEMRA (cells/μl) | 111(63,181) | 119(77,193) | 103(58,185) | 103(54,164) | 121(83,189) | 115(63,194) | 0.281 |