Table 2 Features of histological scoring and features of C3GN and C3 Control biopsy samples
Histology features | C3GN patients (n = 10) | C3 Control (n = 21) | p value |
|---|---|---|---|
Light Microscopy patterns | |||
Normal (%) | 10 (n = 1) | 14 (n = 3) | 1 |
MPGN (%) | 60 (n = 6) | 5 (n = 1) | < 0.01 |
Mesangial proliferation (%) | 30 (n = 3) | 57 (n = 12) | 0.3 |
Endocapillary proliferation (%) | 40 (n = 4) | 14 (n = 3) | 0.2 |
Leucocyte infiltration (%) | 30 (n = 3) | 19 (n = 4) | 0.7 |
Cellular or fibrocellular crescents (%) | 30 (n = 3) | 38 (n = 7) | 1 |
Immunofluorescence | |||
C3 alone (%) | 80 (n = 8) | 24 (n = 5) | 0.05 |
C3 dominant (with trace or 1+ Ig) (%) | 20 (n = 2) | 38 (n = 7) | 0.4 |
C3 dominant (with trace > 2+ Ig) (%) | 0 | 38 (n = 7) | 0.03 |
Electron microscopy findings | |||
No deposits (%) | 0 | 38 (n = 7) | 0.02 |
Any deposits (%) | 100 (n = 10) | 62 (n = 13) | 0.5 |
Mesangial (%) | 40 (n = 4) | 19 (n = 4) | 0.7 |
Subendothelial (%) | 20 (n = 2) | 24 (n = 5) | 0.6 |
Subepithelial (%) | 10 (n = 1) | 5 (n = 1) | 1.00 |
All 3 locations (%) | 30 (n = 3) | 14 (n = 3) | 0.4 |
Deposit features | |||
Amorphous (%) | 50 (n = 5) | 5 (n = 1) | 0.007 |
Dense (%) | 10 (n = 1) | 14 (n = 3) | 0.6 |
Patchy (%) | 30 (n = 3) | 52 (n = 11) | 0.2 |
Subendothelial humps (%) | 10 (n = 1) | 30 (n = 6) | 0.4 |