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Table 2 Features of histological scoring and features of C3GN and C3 Control biopsy samples

From: The impact of reclassification of C3 predominant glomerulopathies on diagnostic accuracy, outcome and prognosis in patients with C3 glomerulonephritis

Histology features C3GN patients
(n = 10)
C3 Control
(n = 21)
p value
Light Microscopy patterns
 Normal (%) 10 (n = 1) 14 (n = 3) 1
 MPGN (%) 60 (n = 6) 5 (n = 1) < 0.01
 Mesangial proliferation (%) 30 (n = 3) 57 (n = 12) 0.3
 Endocapillary proliferation (%) 40 (n = 4) 14 (n = 3) 0.2
 Leucocyte infiltration (%) 30 (n = 3) 19 (n = 4) 0.7
 Cellular or fibrocellular crescents (%) 30 (n = 3) 38 (n = 7) 1
Immunofluorescence
 C3 alone (%) 80 (n = 8) 24 (n = 5) 0.05
 C3 dominant (with trace or 1+ Ig) (%) 20 (n = 2) 38 (n = 7) 0.4
 C3 dominant (with trace > 2+ Ig) (%) 0 38 (n = 7) 0.03
Electron microscopy findings
 No deposits (%) 0 38 (n = 7) 0.02
 Any deposits (%) 100 (n = 10) 62 (n = 13) 0.5
 Mesangial (%) 40 (n = 4) 19 (n = 4) 0.7
 Subendothelial (%) 20 (n = 2) 24 (n = 5) 0.6
 Subepithelial (%) 10 (n = 1) 5 (n = 1) 1.00
 All 3 locations (%) 30 (n = 3) 14 (n = 3) 0.4
Deposit features
 Amorphous (%) 50 (n = 5) 5 (n = 1) 0.007
 Dense (%) 10 (n = 1) 14 (n = 3) 0.6
 Patchy (%) 30 (n = 3) 52 (n = 11) 0.2
 Subendothelial humps (%) 10 (n = 1) 30 (n = 6) 0.4