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Table 1 Summary of clinical and biological characteristics of Cases 1 and 2

From: Ockham’s razor defeated: about two atypical cases of hemolytic uremic syndrome

  Patient 1 Patient 2
Clinical presentation No fever
Elevated blood pressure
Vomiting and diarrhea
Skin purpura
Fever
Normal blood pressure
Vomiting, no diarrhea
Skin purpura
Arthralgia and myalgia
Biological presentation KDIGO stage 3 AKI
Proteinuria 6 g/24 h
Microscopic haematuria
Hemoglobin 13.1 g/dL
Platelets 47,000/mm3
Schistocytes 1%
LDH 740 UI/L
KDIGO stage 3 AKI
Proteinuria 2 g/24 h
Microscopic haematuria
Hemoglobin 10 g/dL
Platelets 71,000/mm3
Schistocytes 1.7%
LDH 864 UI/L
Complement exploration Normal C3
Normal C4
Normal Factor H, Factor I, MCP
Absence of anti-Factor H antibodies
Moderately low C3
Normal C4
Normal Factor H, Factor I, MCP
Absence of anti-Factor H antibodies
Microbiological evidence of STEC Stool culture positive for E. coli O128 serotype
PCR positive for stx2b and ehxa genes
Stool culture positive for E. coli O26 serotype
PCR positive for stx1a, eae and ehxa genes
Other cause of HUS Presence of a heterozygous CFHR1/CFH hybrid gene Parvovirus B19 primo-infection
Recurrence Yes No