From: Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy
Characteristics | PGN (n = 30) | PGN with DM (n = 30) | DN (n = 30) | p value |
---|---|---|---|---|
Female, n (%) | 11 (36.7%) | 10 (33.3%) | 6 (20%) | 0.274 |
Age (years) | 47.17 ± 13.60 | 51.73 ± 14.06 | 50.57 ± 11.71 | 0.382 |
Diabetes duration (years) | 0 | 3.77 ± 3.87 | 9.94 ± 6.77 | < 0.001 |
Hypertension (years) | 3.07 ± 3.94 | 3.77 ± 5.73 | 6.19 ± 7.45 | 0.105 |
Hypertension, n (%) | 15 (50%) | 16 (53.3%) | 24 (80%) | 0.033 |
SBP (mmHg) | 133.73 ± 16.26 | 134.00 ± 17.66 | 146.00 ± 25.19 | 0.030 |
DBP (mmHg) | 85.07 ± 11.72 | 84.00 ± 9.69 | 88.47 ± 13.48 | 0.310 |
Hb (g/L) | 139.90 ± 14.11 | 137.40 ± 17.10 | 109.07 ± 22.51 | < 0.001 |
HbA1C (%) | 5.61 ± 0.59 | 7.15 ± 1.30 | 7.57 ± 1.94 | 0.002 |
Fasting glucose (mmol/L) | 4.94 ± 0.96 | 6.57 ± 1.84 | 8.20 ± 4.95 | < 0.001 |
Total cholesterol (mg/dL) | 6.47 ± 3.53 | 6.85 ± 2.78 | 5.66 ± 1.74 | 0.293 |
LDL cholesterol (mg/dL) | 4.20 ± 2.39 | 4.46 ± 1.90 | 3.80 ± 1.30 | 0.180 |
HDL cholesterol (mg/dL) | 1.34 ± 0.45 | 1.27 ± 0.41 | 1.16 ± 0.39 | 0.396 |
Triglyceride (mg/dL) | 2.10 ± 1.51 | 3.40 ± 2.40 | 1.96 ± 1.84 | 0.004 |
Albumin (g/L) | 32.93 ± 11.12 | 29.79 ± 9.67 | 32.24 ± 6.19 | 0.388 |
Serum creatinine (umol/L) | 73.24 ± 21.51 | 84.65 ± 51.27 | 155.84 ± 95.87 | < 0.001 |
eGFR (ml/min/1.73 m2) | 100.10 ± 20.16 | 92.15 ± 27.99 | 59.64 ± 33.42 | < 0.001 |
Serum cystatin C (mg/L) | 1.07 ± 0.27 | 1.28 ± 0.51 | 2.05 ± 0.96 | 0.002 |
BUN (mmol/L) | 5.44 ± 1.18 | 5.79 ± 2.06 | 10.63 ± 6.19 | < 0.001 |
Uric acid (umol/L) | 370.60 ± 87.13 | 387.97 ± 83.67 | 405.54 ± 103.96 | 0.344 |
Serum NGAL (ng/mL) | 169.18 ± 96.86 | 238.54 ± 112.51 | 227.65 ± 149.28 | 0.053 |
Urine NGAL (ng/mL) | 60.99 ± 116.73 | 95.43 ± 186.92 | 96.73 ± 146.77 | 0.394 |
Urine albumin(g/24 h) | 3.44 ± 4.59 | 4.97 ± 4.62 | 5.50 ± 5.10 | 0.037 |
Urine ACR (mg/g) | 119.71 ± 110.37 | 287.55 ± 146.89 | 465.32 ± 304.63 | < 0.001 |
Urine pH | 6.09 ± 0.57 | 5.89 ± 0.56 | 5.94 ± 0.66 | 0.398 |
Urine bicarbonate (mmol/L) | 24.70 ± 2.42 | 24.63 ± 1.57 | 25.26 ± 2.21 | 0.324 |
Urine titratable acid (mmol/L) | 24.03 ± 16.62 | 18.26 ± 10.12 | 12.59 ± 9.78 | 0.011 |
Urine ammonia (mmol/L) | 44.67 ± 26.83 | 31.74 ± 18.89 | 18.48 ± 12.83 | < 0.001 |