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Table 1 Baseline characteristics in patients (n = 90)

From: Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy

Characteristics PGN
(n = 30)
PGN with DM
(n = 30)
DN
(n = 30)
p value
Female, n (%) 11 (36.7%) 10 (33.3%) 6 (20%) 0.274
Age (years) 47.17 ± 13.60 51.73 ± 14.06 50.57 ± 11.71 0.382
Diabetes duration (years) 0 3.77 ± 3.87 9.94 ± 6.77 < 0.001
Hypertension (years) 3.07 ± 3.94 3.77 ± 5.73 6.19 ± 7.45 0.105
Hypertension, n (%) 15 (50%) 16 (53.3%) 24 (80%) 0.033
SBP (mmHg) 133.73 ± 16.26 134.00 ± 17.66 146.00 ± 25.19 0.030
DBP (mmHg) 85.07 ± 11.72 84.00 ± 9.69 88.47 ± 13.48 0.310
Hb (g/L) 139.90 ± 14.11 137.40 ± 17.10 109.07 ± 22.51 < 0.001
HbA1C (%) 5.61 ± 0.59 7.15 ± 1.30 7.57 ± 1.94 0.002
Fasting glucose (mmol/L) 4.94 ± 0.96 6.57 ± 1.84 8.20 ± 4.95 < 0.001
Total cholesterol (mg/dL) 6.47 ± 3.53 6.85 ± 2.78 5.66 ± 1.74 0.293
LDL cholesterol (mg/dL) 4.20 ± 2.39 4.46 ± 1.90 3.80 ± 1.30 0.180
HDL cholesterol (mg/dL) 1.34 ± 0.45 1.27 ± 0.41 1.16 ± 0.39 0.396
Triglyceride (mg/dL) 2.10 ± 1.51 3.40 ± 2.40 1.96 ± 1.84 0.004
Albumin (g/L) 32.93 ± 11.12 29.79 ± 9.67 32.24 ± 6.19 0.388
Serum creatinine (umol/L) 73.24 ± 21.51 84.65 ± 51.27 155.84 ± 95.87 < 0.001
eGFR (ml/min/1.73 m2) 100.10 ± 20.16 92.15 ± 27.99 59.64 ± 33.42 < 0.001
Serum cystatin C (mg/L) 1.07 ± 0.27 1.28 ± 0.51 2.05 ± 0.96 0.002
BUN (mmol/L) 5.44 ± 1.18 5.79 ± 2.06 10.63 ± 6.19 < 0.001
Uric acid (umol/L) 370.60 ± 87.13 387.97 ± 83.67 405.54 ± 103.96 0.344
Serum NGAL (ng/mL) 169.18 ± 96.86 238.54 ± 112.51 227.65 ± 149.28 0.053
Urine NGAL (ng/mL) 60.99 ± 116.73 95.43 ± 186.92 96.73 ± 146.77 0.394
Urine albumin(g/24 h) 3.44 ± 4.59 4.97 ± 4.62 5.50 ± 5.10 0.037
Urine ACR (mg/g) 119.71 ± 110.37 287.55 ± 146.89 465.32 ± 304.63 < 0.001
Urine pH 6.09 ± 0.57 5.89 ± 0.56 5.94 ± 0.66 0.398
Urine bicarbonate (mmol/L) 24.70 ± 2.42 24.63 ± 1.57 25.26 ± 2.21 0.324
Urine titratable acid (mmol/L) 24.03 ± 16.62 18.26 ± 10.12 12.59 ± 9.78 0.011
Urine ammonia (mmol/L) 44.67 ± 26.83 31.74 ± 18.89 18.48 ± 12.83 < 0.001