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Table 2 Baseline characteristics according to discrepancy between the trends of eGFRCr and eGFRCysC

From: Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort

 

Discrepancy

(n = 55)

Agreement

(n = 706)

P

Age (years)

44.8 ± 10.3

56.8 ± 10.7

< 0.001

Male (%)

61.8

62.2

0.957

Age-adjusted Charlson comorbidity index (%)

2.4 ± 1.7

4.0 ± 1.7

< 0.001

 Low (≤3)

74.5

42.9

 

 Moderate (4–5)

21.8

36.5

 

 High (6–7)

3.6

18.1

 

 Very high (≥8)

0

2.4

 

Diabetes (%)

27.3

31.4

0.622

Hypertension (%)

98.2

98.9

1.000

Systolic blood pressure (mmHg)

128.0 ± 13.0

125.9 ± 14.7

0.306

Diastolic blood pressure (mmHg)

78.4 ± 10.7

75.7 ± 10.1

0.062

Body mass index (kg/m2)

24.4 ± 4.0

24.7 ± 3.3

0.514

Body surface area (m2)

1.8 ± 0.2

1.7 ± 0.2

0.036

Systolic blood pressure (mmHg)

128.0 ± 13.0

125.9 ± 14.7

0.306

Diastolic blood pressure (mmHg)

78.4 ± 10.7

75.7 ± 10.1

0.062

Cause of chronic kidney disease (%)

  

0.924

 Non-diabetic nephropathy

81.8

80.3

 

 Diabetic nephropathy

18.2

19.7

 

eGFR (ml/min/1.73 m2)

 eGFRCr

66.4 ± 16.6

41.9 ± 15.2

< 0.001

 eGFRCysC

58.2 ± 19.72

41.6 ± 17.9

< 0.001

 eGFRCrCysC

61.0 ± 18.3

40.8 ± 16.1

< 0.001

Laboratory findings

 Hemoglobin (g/dL)

13.4 ± 1.7

12.9 ± 1.9

0.029

 Blood urea nitrogen (mg/dL)

20.8 ± 5.8

20.2 ± 8.6

< 0.001

 Uric acid (mg/dL)

6.8 ± 1.7

7.4 ± 1.7

0.020

 Phosphorus (mg/dL)

3.5 ± 0.5

3.6 ± 0.6

0.041

 Total bilirubin (mg/dL)

0.7 ± 0.3

0.7 ± 0.3

0.087

 Albumin (g/dL)

4.2 ± 0.3

4.2 ± 0.3

0.967

uPCR (mean, interquartile range)

0.5 (0.2–1.5)

0.4 (0.1–1.0)

0.054

  < 0.3 g/g (%)

30.9

41.3

0.011

 0.3–0.9 g/g (%)

27.3

33.1

 

 1.0–3.0 g/g (%)

27.3

20.6

 

  ≥ 3.0 g/g (%)

14.5

5.0

 

uACR (mean, interquartile range g)

427 (120–1206)

295 (72–744)

0.040

  < 30 mg/g (%)

7.3

14.5

0.202

 30–299 mg/g (%)

32.7

36.1

 

  ≥ 300 mg/g (%)

60.0

49.4

 
  1. eGFR Estimated glomerular filtration rate; Cr Creatinine; CysC Cystatin C; uPCR Urine protein/creatinine ratio; uACR Urine albumin creatinine ratio