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Table 2 Baseline characteristics according to discrepancy between the trends of eGFRCr and eGFRCysC

From: Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort

  Discrepancy
(n = 55)
Agreement
(n = 706)
P
Age (years) 44.8 ± 10.3 56.8 ± 10.7 < 0.001
Male (%) 61.8 62.2 0.957
Age-adjusted Charlson comorbidity index (%) 2.4 ± 1.7 4.0 ± 1.7 < 0.001
 Low (≤3) 74.5 42.9  
 Moderate (4–5) 21.8 36.5  
 High (6–7) 3.6 18.1  
 Very high (≥8) 0 2.4  
Diabetes (%) 27.3 31.4 0.622
Hypertension (%) 98.2 98.9 1.000
Systolic blood pressure (mmHg) 128.0 ± 13.0 125.9 ± 14.7 0.306
Diastolic blood pressure (mmHg) 78.4 ± 10.7 75.7 ± 10.1 0.062
Body mass index (kg/m2) 24.4 ± 4.0 24.7 ± 3.3 0.514
Body surface area (m2) 1.8 ± 0.2 1.7 ± 0.2 0.036
Systolic blood pressure (mmHg) 128.0 ± 13.0 125.9 ± 14.7 0.306
Diastolic blood pressure (mmHg) 78.4 ± 10.7 75.7 ± 10.1 0.062
Cause of chronic kidney disease (%)    0.924
 Non-diabetic nephropathy 81.8 80.3  
 Diabetic nephropathy 18.2 19.7  
eGFR (ml/min/1.73 m2)
 eGFRCr 66.4 ± 16.6 41.9 ± 15.2 < 0.001
 eGFRCysC 58.2 ± 19.72 41.6 ± 17.9 < 0.001
 eGFRCrCysC 61.0 ± 18.3 40.8 ± 16.1 < 0.001
Laboratory findings
 Hemoglobin (g/dL) 13.4 ± 1.7 12.9 ± 1.9 0.029
 Blood urea nitrogen (mg/dL) 20.8 ± 5.8 20.2 ± 8.6 < 0.001
 Uric acid (mg/dL) 6.8 ± 1.7 7.4 ± 1.7 0.020
 Phosphorus (mg/dL) 3.5 ± 0.5 3.6 ± 0.6 0.041
 Total bilirubin (mg/dL) 0.7 ± 0.3 0.7 ± 0.3 0.087
 Albumin (g/dL) 4.2 ± 0.3 4.2 ± 0.3 0.967
uPCR (mean, interquartile range) 0.5 (0.2–1.5) 0.4 (0.1–1.0) 0.054
  < 0.3 g/g (%) 30.9 41.3 0.011
 0.3–0.9 g/g (%) 27.3 33.1  
 1.0–3.0 g/g (%) 27.3 20.6  
  ≥ 3.0 g/g (%) 14.5 5.0  
uACR (mean, interquartile range g) 427 (120–1206) 295 (72–744) 0.040
  < 30 mg/g (%) 7.3 14.5 0.202
 30–299 mg/g (%) 32.7 36.1  
  ≥ 300 mg/g (%) 60.0 49.4  
  1. eGFR Estimated glomerular filtration rate; Cr Creatinine; CysC Cystatin C; uPCR Urine protein/creatinine ratio; uACR Urine albumin creatinine ratio