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Table 3 Analysis to identify conditions related to discrepant trends of eGFRCr and eGFRCysC

From: Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort

 

Model 1

Model 2

Variables

OR (95% CI)

P

OR (95% CI)

P

Age

0.92 (0.89–0.95)

< 0.001

0.92 (0.89–0.95)

< 0.001

Male

1.60 (0.61–4.26)

0.343

  

Age-adjusted CCI

 Low (≤3)

Reference

   

 Moderate (4–5)

1.30 (0.53–3.12)

0.563

  

 High (6–7)

1.66 (0.28–7.28)

0.541

  

 Very high (≥8)

2.48 (0.02–30.54)

0.608

  

Body surface area

2.01 (0.18–20.83)

0.562

  

Diastolic blood pressure

1.01 (0.98–1.04)

0.579

  

Hemoglobin

0.90 (0.71–1.13)

0.350

  

Blood urea nitrogen

0.99 (0.92–1.05)

0.661

  

Uric acid

0.91 (0.74–1.12)

0.379

  

Phosphorus

0.83 (0.42–1.62)

0.590

  

Total bilirubin

2.00 (0.52–7.35)

0.307

  

uPCR (g/g)

  < 0.3

Reference

 

Reference

 

 0.3–0.9

1.69 (0.49–5.26)

0.392

1.53 (0.68–3.45)

0.305

 1.0–3.0

4.54 (0.95–21.44)

0.058

3.32 (1.43–7.84)

0.006

  ≥ 3.0

17.87 (3.14–102.19)

0.001

12.38 (4.07–37.39)

< 0.001

uACR (mg/g)

  < 30

Reference

   

 30–299

2.53 (0.74–10.73)

0.145

  

  ≥ 300

1.55 (0.27–10.19)

0.630

  

eGFRCrCysC

1.07 (1.04–1.10)

< 0.001

1.07 (1.05–1.09)

< 0.001

  1. Model 1: Adjusted for age, sex, eGFRCrCys and the variables which had P value less than 0.1 in univariate analysis
  2. Model 2: Model 1 with backward elimination method
  3. CCI Charlson comorbidities index; OR Odds ratio; CI Confidence interval; uPCR Urine protein/creatinine ratio; uACR Urine albumin/creatinine ratio; eGFR, estimated glomerular filtration rate; Cr Creatinine; CysC Cystatin C
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BMC Nephrology

ISSN: 1471-2369

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