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Table 3 Analysis to identify conditions related to discrepant trends of eGFRCr and eGFRCysC

From: Discrepant glomerular filtration rate trends from creatinine and cystatin C in patients with chronic kidney disease: results from the KNOW-CKD cohort

  Model 1 Model 2
Variables OR (95% CI) P OR (95% CI) P
Age 0.92 (0.89–0.95) < 0.001 0.92 (0.89–0.95) < 0.001
Male 1.60 (0.61–4.26) 0.343   
Age-adjusted CCI
 Low (≤3) Reference    
 Moderate (4–5) 1.30 (0.53–3.12) 0.563   
 High (6–7) 1.66 (0.28–7.28) 0.541   
 Very high (≥8) 2.48 (0.02–30.54) 0.608   
Body surface area 2.01 (0.18–20.83) 0.562   
Diastolic blood pressure 1.01 (0.98–1.04) 0.579   
Hemoglobin 0.90 (0.71–1.13) 0.350   
Blood urea nitrogen 0.99 (0.92–1.05) 0.661   
Uric acid 0.91 (0.74–1.12) 0.379   
Phosphorus 0.83 (0.42–1.62) 0.590   
Total bilirubin 2.00 (0.52–7.35) 0.307   
uPCR (g/g)
  < 0.3 Reference   Reference  
 0.3–0.9 1.69 (0.49–5.26) 0.392 1.53 (0.68–3.45) 0.305
 1.0–3.0 4.54 (0.95–21.44) 0.058 3.32 (1.43–7.84) 0.006
  ≥ 3.0 17.87 (3.14–102.19) 0.001 12.38 (4.07–37.39) < 0.001
uACR (mg/g)
  < 30 Reference    
 30–299 2.53 (0.74–10.73) 0.145   
  ≥ 300 1.55 (0.27–10.19) 0.630   
eGFRCrCysC 1.07 (1.04–1.10) < 0.001 1.07 (1.05–1.09) < 0.001
  1. Model 1: Adjusted for age, sex, eGFRCrCys and the variables which had P value less than 0.1 in univariate analysis
  2. Model 2: Model 1 with backward elimination method
  3. CCI Charlson comorbidities index; OR Odds ratio; CI Confidence interval; uPCR Urine protein/creatinine ratio; uACR Urine albumin/creatinine ratio; eGFR, estimated glomerular filtration rate; Cr Creatinine; CysC Cystatin C