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Table 2 SNPs Most Associated with AKI-SP2

From: Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes

SNP

Associated Gene

Chromosome: Coordinate

Function

Minor Allele Frequency

(1000 Genomes)

Odds Ratio

(95% CI)a

P-value

FDR Corrected P-value

1. rs2920656

MCPH1

Chr8:6329510

Intron

0.284

0.45 (0.31–0.66)

1.38 × 10−5

0.0026

2. rs2442473

ANGPT2 MCPH1

Chr8:6358293

Intron

0.082

0.40 (0.22–0.74)

0.001902

0.0723

3. rs2920689

MCPH1

Chr8:6343499

Intron

0.310

0.59 (0.42–0.82)

0.001538

0.0731

4. rs2959779

MCPH1

Chr8:6443380

Intron

0.055

0.27 (0.11–0.67)

0.001307

0.0828

5. rs2440399

MCPH1

Chr8:6325975

Intron

0.207

0.52 (0.34–0.78)

0.000984

0.0935

  1. Definition of abbreviations: SNP single nucleotide polymorphism, CI confidence interval, FDR False Discovery Rate
  2. aAdditive genetic model adjusted for age, gender, sepsis and 5 principal components