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Table 5 Multivariate analysis for cardiovascular and all-cause mortality in patients undergoing hemodialysis

From: Serum levels of protein carbonyl, a marker of oxidative stress, are associated with overhydration, sarcopenia and mortality in hemodialysis patients

 

Cardiovascular

All–cause

HR (95% CI)

P

HR (95% CI)

P

Age

1.07 (1.01–1.13)

0.014

1.07 (1.03–1.11)

0.001

Gender (male vs. female)

1.12 (0.29–4.32)

0.870

0.67 (0.24–1.90)

0.453

Body mass index

1.11 (0.90–1.36)

0.348

1.01 (0.87–1.18)

0.904

Diabetes

1.05 (0.29–3.83)

0.723

1.52 (0.62–3.65)

0.363

CAD

4.45 (1.22–16.12)

0.024

2.58 (1.10–6.72)

0.015

CVD

1.42 (0.87–3.16)

0.420

0.64 (0.39–2.00)

0.318

PAOD

3.89 (1.01–18.41)

0.043

2.11 (0.94–20.8)

0.054

Dialysis vintage

1.01 (0.99–1.03)

0.256

1.00 (0.99–1.01)

0.613

IL-6 (log units)

3.38 (1.16–7.22)

0.002

2.93 (1.83–4.69)

0.001

Hs-CRP (log units)

1.75 (1.09–2.82)

0.021

1.89 (1.37–2.60)

< 0.001

Albumin

0.07 (0.16–0.37)

0.002

0.17 (0.06–0.46)

0.003

Prealbumin

0.85 (0.76–0.95)

0.003

0.86 (0.80–0.92)

0.001

SGA (B vs. A)

3.86 (1.87–23.87)

0.003

6.51 (2.72–15.61)

< 0.001

Sarcopenia

7.71 (1.83–32.57)

0.017

2.72 (1.11–6.63)

0.028

Overhydration

3.43 (0.77–15.23)

0.184

2.31 (1.26–8.71)

0.015

Carbonyl (log units)

6.90 (1.86–25.58)

0.004

2.37 (1.02–5.55)

0.036

  1. Multivariate logistic analysis was performed after adjusting for age, gender, BMI, diabetes, CAD, CVD, PAOD and dialysis vintage
  2. CAD coronary artery disease, CVD cerebrovascular disease, PAOD peripheral artery disease, hs-CRP high-sensitivity C-reactive protein, SGA subjective global assessment