Table 2 Renal histology
Patient | No glomeruli (No globally sclerosed) | Pattern of glomerular inflammation | Arteriolar necrosis, thrombosis | Interstitial inflammatory infiltrate | Interstitial fibrosis (< 5%) | Pseudothrombi | Glomerular IHC (paraffin-IF) | Deposits on EM |
|---|---|---|---|---|---|---|---|---|
1 | 25 (0) | Early MPGN | No | Patchy, mild | < 5% | Yes | Loop focal IgM+ (κ-, λ-) Pseudothrombi IgG+, IgM+++ (κ+++, λ+++) | Unstructured |
2 | 18 (6) | Crescents (5 cellular, 1 fibro-cellular, 2 fibrous) | Yes | Light, chronic | 40% | No | Mesangial focal IgM++, C3++ (κ+, λ+) | – |
3 | 20 (5) | MPGN, endocapillary (CD68+) | No | Light, chronic | 25% | Yes | Loop and pseudothrombi IgG++, IgM+++, IgA+, C3+++, C1q++ (κ ++, λ ++) | Unstructured |
4 | 18 (2) | MPGN | No | Moderate | 25% | Sparse | Mesangial and loop IgG+, IgM++, IgA+, C3++ (κ -, λ -) | Fine curvilinear |