Noninfectious mixed cryoglobulinaemic glomerulonephritis and monoclonal gammopathy of undetermined significance: a coincidental association?

Table 3 Biochemistry at time of renal biopsy

Patient	Serum cryoglobulin			Paraprotein						Peripheral blood flow cytometry
	Concentration (g/L)	Type	RF	SPEP (g/L)	SIFE	SFLC^a			Spot UPEP/UIFE
	Concentration (g/L)	Type	RF	SPEP (g/L)	SIFE	κ (3.3–19.4 mg/L)	λ (5.7–26.3 mg/L)	κ /λ (0.26–1.65)	Spot UPEP/UIFE
1	0.1	2 or 3	Neg	2	IgM-κ	26.6	5.5	4.84	Neg	Normal
2	0.43	2 (mIgM-κ + pIgG)	Pos	< 1	IgM-κ, IgG-κ	231.9	65.3	3.55	Neg	Normal
3	0.62	3 (pIgM + pIgG)	Pos	< 1	IgM-κ	49.0	27.5	1.78	Neg	Not assessed
4	9% cryocrit	2 (mIgM-κ + pIgG)	Pos	< 1	IgM-κ	157.0	17.4	9.02	IgM-κ	Normal

RF rheumatoid factor; SPEP serum protein electrophoresis; SIFE serum immunofixation; SFLC serum free light chains; κ kappa; λ lambda; UPEP/UIFE urine protein electrophoresis/immunofixation; mIg monoclonal immunoglobulin; pIg polyclonal immunoglobulin
^aFreelite assay, The Binding Site Group, Birmingham, UK

ISSN: 1471-2369