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Table 5 Treatment and last follow-up

From: Noninfectious mixed cryoglobulinaemic glomerulonephritis and monoclonal gammopathy of undetermined significance: a coincidental association?

Patient

Treatment received

Recurrent vasculitis

Urine PCR (< 30 mg/mmol)

Serum creatinine (μmol/L)

eGFRa (mL/min per 1.73 m2)

Serum cryoglobulin

C3 (0.9–1.8 g/L)

C4 (0.16–0.5 g/L)

Paraprotein

Follow up duration (Years)

SPEP/SIFE

SFLCb κ/λ (0.26–1.65)

Spot UPEP/UIFE

1

CS/PE/CYC

No

41

62

90

Neg

1.08

0.18

Neg

0.95

Neg

1.5

2

CS/PE/CYC/AZA

No

24

159

30

Neg

0.93

0.25

Neg

1.29

Neg

2

3

CS/PE/RTX

Yes

165

168

38

Neg

0.84

< 0.03

IgM-κ (< 1 g/L)

1.47

Neg

5

4

CS/CYC/RTX/MS

No

302

106

51

Neg

1.55

< 0.03

Neg

2.09

Neg

11

  1. PCR protein creatinine ratio; eGFR estimated glomerular filtration rate; SPEP/SIFE serum protein electrophoresis/immunofixation; SFLC serum free light chains; κ kappa; λ lambda; CS corticosteroids; PE plasma exchange; CYC cyclophosphamide; AZA azathioprine; RTX rituximab; MS mycophenolate sodium
  2. a MDRD
  3. b Freelite, UK