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Table 3 Simple linear regression for eGFR slope

From: Renal histology in diabetic nephropathy predicts progression to end-stage kidney disease but not the rate of renal function decline

 

Parameter

Coefficient

Confidence interval

P value

R2

Univariate analysis

Age

-Per 10 year increase

2.51

-0.43 – 5.44

0.1

0.06

Male Sex

1.05

-5.21 – 7.30

0.7

0.002

eGFR at biopsy

-Per 1ml/min increase

-0.09

-0.22 – 0.46

0.2

0.03

ACR

-Per 100 mg/mmol increase)

-1.24

-2.06 – 0.42

0.005

0.16

HbA1c

-Per 1% increase

-1.60

-2.71 – -0.49

0.007

0.14

SBP

-Per 10 mmHg increase

-0.21

-1.64 – 1.21

0.8

0.002

Glomerular class

(reference: Low)

-High

1.49

-6.70 – 9.67

0.7

0.003

IF/TA score

(reference: Low)

-High

3.26

-3.12 – 9.63

0.3

0.02

Arteriolar Hyalinosis score (reference: Low)

-High

-0.62

-6.64 – 5.41

0.8

0.0008

Arteriosclerosis score

(reference: Low)

-High

0.408

-5.85 – 6.67

0.9

0.0003

Final multivariable model

(p = 0.002)

ACR

-Per 100mg/mmol increase

-0.87

-1.73 – 0.009

0.05

0.21

HbA1C

-Per 1% increase

-1.34

-2.51 - -0.18

0.03

 
  1. Legend: eGFR estimated glomerular filtration rate, ACR urinary albumin-to-creatinine ratio, HbA1c hemoglobin A1c, SBP systolic blood pressure, IF/TA interstitial fibrosis and tubular atrophy