Table 3 Patient characteristics (N = 32,492)
From: Renal function deterioration in adult patients with type-2 diabetes
|  | eGFR-increasea > 12 (27.1% of pts) | eGFR-increasea 0 up to + 12 (18.6% of pts) | eGFR-slopea 0 down to − 12 (23.4% of pts) | eGFR-slopea − 12 or smaller (30.9% of pts) |
|---|---|---|---|---|
Age, years | 56.9 ± 10.2 | 66.9 ± 9.0 | 69.8 ± 8.5 | 74.1 ± 8.2 |
Male gender, % | 57.3 | 57.5 | 51.2 | 43.9 |
Body mass index, kg/m2 | 32.5 ± 6.7 | 31.0 ± 5.8 | 31.2 ± 5.9 | 31.7 ± 6.0 |
Diabetes duration, years | 9.1 ± 6.9 | 10.8 ± 8.0 | 11.7 ± 8.7 | 14.0 ± 9.5 |
HbA1c, % | 7.0 ± 1.1 | 6.9 ± 0.9 | 6.9 ± 0.9 | 7.0 ± 0.9 |
Antidiabetic drug treatment | ||||
 Insulin, % | 41.8 | 41.8 | 44.6 | 54.6 |
 Metformin, % | 68.6 | 61.8 | 58.4 | 37.5 |
 DPP4-inhibitors, % | 17.1 | 14.1 | 15.9 | 19.1 |
 Sulfonylurea, % | 18.1 | 20.6 | 20.3 | 19.3 |
 Glinides, % | 6.4 | 6.8 | 7.0 | 9.7 |
 Acarbose, % | 1.7 | 2.1 | 2.1 | 2.5 |
 Sensitizers, % | 4.8 | 4.6 | 4.2 | 4.3 |
 GLP-1 analogues, % | 11.2 | 5.8 | 4.8 | 3.3 |
 SGLT-2 inhibitors, % | 7.3 | 3.6 | 3.0 | 1.9 |
Hypertension, % | 83.6 | 88.0 | 89.9 | 91.8 |
 Syst. blood pressure, mmHg | 134.9 ± 12.4 | 136.1 ± 12.3 | 135.8 ± 12.4 | 135.5 ± 12.7 |
 Diast. blood pressure, mmHg | 80.9 ± 7.1 | 78.9 ± 6.9 | 78.1 ± 7.0 | 76.2 ± 7.3 |
 Antihypertensive drug treatment, % | 60.0 | 66.5 | 69.5 | 73.9 |
  ACEi, % | 35.3 | 37.1 | 38.4 | 40.7 |
  ARBs, % | 18.0 | 20.6 | 22.1 | 26.2 |
  Betablockers, % | 26.4 | 32.4 | 37.8 | 45.5 |
  Calcium channel blockers, % | 18.5 | 22.5 | 24.1 | 30.5 |
  Diuretics, % | 19.6 | 26.9 | 32.7 | 49.5 |
Dyslipidemia, % | 68.7 | 68.2 | 69.2 | 59.1 |
Kidney parameters | ||||
 eGFR, mL/min/1.73 m2 | 99.8 ± 8.6 | 83.5 ± 4.3 | 70.7 ± 4.5 | 48.5 ± 12.3 |
 Serum potassium, mmol/L | 4.4 ± 0.4 | 4.4 ± 0.4 | 4.4 ± 0.4 | 4.4 ± 0.5 |
Albuminuria | ||||
 Microalbuminuria, % | 42.3 | 40.4 | 41.8 | 50.9 |
 Macroalbuminuria, % | 1.7 | 1.9 | 2.2 | 7.7 |
Comorbidity at baseline | ||||
 Myocardial infarction, % | 5.4 | 8.9 | 10.3 | 14.8 |
 Stroke, % | 3.9 | 7.7 | 8.8 | 12.6 |
 Heart failure, % | 4.1 | 7.3 | 8.1 | 16.1 |
 Peripheral artery disease, % | 22.2 | 31.3 | 35.1 | 44.6 |
 Major amputation, % | 0.5 | 0.7 | 0.9 | 1.2 |
 Minor amputation, % | 0.9 | 1.4 | 1.9 | 3.4 |
 Diabetic neuropathy, % | 61.1 | 68.7 | 72.2 | 77.9 |
 Diabetic foot syndrome, % | 18.6 | 23.8 | 27.4 | 32.2 |
 Diabetic retinopathy, % | 9.6 | 11.6 | 14.3 | 19.1 |