Mannitol (n = 16) | Placebo (n = 16) | p- Value | |||
---|---|---|---|---|---|
Duration | |||||
Anesthesia, hrs | 3.6 | [3.1, 4.1] | 3.8 | [3.4, 4.3] | 0.35 |
Surgery, hrs | 2.6 | [2.2, 3.2] | 2.9 | [2.4, 3.5] | 0.55 |
Arterial Clamp, min | 16 | [10, 23] | 24 | [12, 29] | 0.25 |
Venous Clamp, min | 22 | [16, 25] | 20 | [15, 25] | 0.47 |
Fluid & Hemodynamics | |||||
Total Fluid, mL | 1.870 | ±817 | 1.823 | ±558 | 0.85 |
Blood Loss, mL | 200 | [100, 588] | 175 | [0, 375] | 0.49 |
MAP, TWA mmHg | 77 | [74, 91] | 79 | [74, 82] | 0.74 |
SV, mL | 51 | [43, 82] | 64 | [52, 72] | 0.74 |
CO, L min−1 | 3.1 | [2.5, 5.0] | 4.3 | [2.9, 4.7] | 0.97 |
CVP, mmHg | 13 | ±4 | 12 | ±4 | 0.47 |
Anesthesia Variables | |||||
Propofol, mg | 190 | [123, 200] | 200 | [90, 230] | 0.92 |
Fentanyl, μg | 650 | [500, 750] | 550 | [400, 800] | 0.92 |
et Sevoflurane TWA, % | 1.3 | ±0.5 | 1.5 | ±0.3 | 0.36 |
SpO2, % | 99 | [98, 99] | 98 | [96, 99] | 0.15 |
Core, T°C | 36.3 | ±0.4 | 36.4 | ±0.5 | 0.32 |
Phenylephrine | |||||
No. of Patients, (%) | 8 | (50) | 11 | (69) | 0.78 |
Cumulative Dose, mg | 0.02 | [0.0, 0.4] | 0.08 | [0.0, 0.19] | 0.99 |
Noradrenaline | |||||
No. of Patients, (%) | 5 | (32) | 5 | (32) | 1.00 |
Cumulative Dose, mg | 0.14 | [0.00, 0.29] | 0.11 | [0.00, 0.20] | 0.86 |
Central Venous Blood Gas Analysis | |||||
pH | 7.36 | ±0.1 | 7.37 | ±0.1 | 0.40 |
pCO2,mmHg | 44 | ±7 | 46 | ±7 | 0.34 |
pO2,mmHg | 49 | [42; 56] | 52 | [46; 56] | 0.38 |
Hb, g/dL | 9.7 | ±1.4 | 9.6 | ±1.3 | 0.62 |
Na+, mmol/L | 136 | ±3 | 138 | ±2 | 0.04 |
K+, mmol/L | 4.7 | ±0.7 | 4.7 | ±0.4 | 0.93 |
Lactate, mmol/L | 0.8 | ±0.2 | 0.8 | ±0.3 | 0.49 |