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Table 4 Cox proportional hazards models exploring the relationship between serum iron levels and 90-day mortality

From: Elevated serum iron level is a predictor of prognosis in ICU patients with acute kidney injury

Factors

Univariate model

Multivariate model

HR (95% CI)

P Value

HR (95% CI)

P Value

Sex (M)

1.524 (1.142–2.034)

0.004

1.308 (0.976–1.753)

0.072

Age (years)

 16–59

Reference

–

Reference

–

  ≥ 60

1.44 (1.065–1.947)

0.018

1.910 (1.372–2.661)

<  0.001

Congestive heart failure

1.012 (0.759–1.348)

0.936

1.115 (0.812–1.531)

0.502

Hypertension

0.7821 (0.589–1.039)

0.090

0.703 (0.520–0.951)

0.022

SOFA score

  < 2

Reference

–

Reference

–

  ≥ 2

2.760 (1.297–5.872)

0.008

1.534 (0.694–3.387)

0.290

Stage of AKI

 Stage 1

Reference

–

Reference

–

 Stage 2

1.119 (0.693–1.807)

0.647

1.102 (0.680–1.786)

0.693

 Stage 3

2.030 (1.376–2.995)

<  0.001

1.587 (1.017–2.477)

0.042

Treatment

 Non-RRT

Reference

–

Reference

–

 RRT

1.505 (1.108–2.043)

0.009

0.816 (0.553–1.203)

0.304

Creatinine

1.112 (1.023–1.208)

0.0127

1.030 (0.928–1.143)

0.577

Transferrin

0.992 (0.989–0.995)

<  0.001

0.994 (0.991–0.997)

<  0.001

Ferritin

1.001 (1.001–1.001)

<  0.001

1.000 (1.000–1.001)

0.086

Iron group

 Low iron group

Reference

–

Reference

–

 High iron group

1.585 (1.190–2.112)

0.002

1.741 (1.285–2.358)

< 0.001

  1. HR Hazard Ratio, CI Confidence Interval, SOFA Sequential Organ Failure Assessment; AKI Acute Kidney Injury, RRT Renal Replacement Therapy