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Table 2 Association between baseline serum indoxyl sulfate levels and clinical parameters

From: New oral spherical carbon adsorbent effectively reduces serum indoxyl sulfate levels in moderate to advanced chronic kidney disease patients: a multicenter, prospective, open-label study

  Univariate Multivariable
B (95% CI) P B (95% CI) P
Age (per 1 year increase) 0.003 (−0.004 to 0.01) 0.36  
BMI (per 1 kg/m2 increase) − 0.014 (− 0.035 to 0.008) 0.22  
SBP (per 1 mmHg increase) 0.004 (− 0.004 to 0.012) 0.31  
eGFR (per 1 mL/min/1.73m2 increase) −0.015 (− 0.022 to − 0.008) < 0.001 −0.013 (− 0.018 to0.001) 0.02
Log-transformed UPCR (per 1 increase) 0.028 (−0.050 to 0.107) 0.46  
Hemoglobin (per 1 mg/dL increase) −0.074 (− 0.123 to − 0.031) 0.001 −0.012 (− 0.059 to 0.034) 0.60
Phosphorus (per 1 mg/dL increase) 0.263 (0.130 to 0.391) < 0.001 0.085 (−0.053 to 0.224) 0.22
Intact PTH (per 1 mg/dL increase) 0.002 (0.001 to 0.003) < 0.001 0.001 (0.000 to 0.002) 0.05
serum albumin (per 1 g/dL increase) −0.024 (− 0.183 to 0.135) 0.77  
  1. Abbreviation: BMI body mass index, SBP systolic blood pressure, eGFR estimated glomerular filtration rate, UPCR urine protein to creatinine ratio, PTH parathyroid hormone