Variable | Rapid progressor (n = 157) | Stable patient (n = 179) | P-value |
---|---|---|---|
Age (years) | 54.0 (43.5–64.0) | 68.4 (58.8–76.5) | < 0.001 |
Men, n (%) | 81 (52) | 128 (72) | < 0.001 |
Caucasian, n (%) | 152 (97) | 174 (97) | 0.833 |
Systolic blood pressure (mmHg) | 144 (133–157) | 137 (122–148) | 0.001 |
Diastolic blood pressure (mmHg) | 82 (74–91) | 74 (66–80) | < 0.001 |
Hypertension, n (%) | 151 (96) | 168 (94) | 0.332 |
Diabetes, n (%) | 41 (26) | 67 (37) | 0.027 |
Body mass index (kg/m2) | 28.0 (24.5–32.0) | 28.0 (24.5–32.2) | 0.925 |
Past/current smoking history, n (%) | 100 (64) | 122 (68) | 0.389 |
Myocardial infarction, n (%) | 5 (3) | 25 (14) | 0.002 |
Peripheral vascular disease, n (%) | 8 (5) | 11 (6) | 0.375 |
Stroke, n (%) | 11 (7) | 5 (3) | 0.138 |
Heart failure, n (%) | 2 (1) | 10 (6) | 0.047 |
ACEi/ARB, n (%) | 112 (71) | 118 (66) | 0.286 |
Statin, n (%) | 92 (58) | 116 (65) | 0.243 |
CKD stage 3, n (%) | 109 (69) | 78 (44) | < 0.001 |
CKD stage 4, n (%) | 48 (31) | 101 (56) | < 0.001 |
Years follow-up | 3.9 (2.9–5.0) | 7.5 (5.7–9.8) | < 0.001 |
Primary renal disease | |||
Diabetic nephropathy, n (%) | 31 (20) | 39 (22) | 0.646 |
ADPKD, n (%) | 52 (33) | 2 (1) | < 0.001 |
Hypertensive nephropathy, n (%) | 11 (7) | 17 (10) | 0.410 |
Renovascular disease, n (%) | 3 (2) | 14 (8) | 0.014 |
Obstructive uropathy, n (%) | 7 (4) | 17 (9) | 0.038 |
Glomerulonephritis, n (%) | 26 (17) | 24 (13) | 0.418 |
Other causes, n (%) | 21 (13) | 39 (22) | 0.045 |
Unknown, n (%) | 6 (4) | 27 (15) | < 0.001 |
Laboratory results | |||
Creatinine (umol/l) | 171 (145–201) | 193 (157–238) | < 0.001 |
eGFR-EPI (ml/min/1.73m2) | 34 (28–41) | 28 (22–37) | < 0.001 |
eGFR measurements, n | 25 (16–36) | 24 (15–38) | 0.960 |
Days between eGFR measurements, n | 47 (24–91) | 84 (39–135) | < 0.001 |
ΔGFR (±ml/min/1.73m2/yr) | −5.930 (−7.345 to −4.810) | −0.030 (−0.290 to 0.170) | < 0.001 |
Bicarbonate (mmol/L) | 22.5 (20.2–25.0) | 23.0 (20.7–24.9) | 0.354 |
Urea (mmol/L) | 12.0 (9.6–15.0) | 13.4 (10.8–17.6) | 0.001 |
Calcium (mmol/L) | 2.31 (2.21–2.37) | 2.28 (2.21–2.37) | 0.350 |
Phosphate (mmol/L) | 1.16 (1.03–1.29) | 1.05 (0.93–1.21) | < 0.001 |
Alkaline phosphatase (mmol/L) | 78 (59–95) | 83 (65–104) | 0.025 |
Albumin (g/L) | 41 (38–44) | 44 (42–46) | < 0.001 |
Total cholesterol/HDL ratio | 3.55 (2.75–4.46) | 3.17 (2.48–4.06) | 0.007 |
C-reactive protein (mg/L) | 2.8 (1.2–7.3) | 2.5 (1.0–5.7) | 0.234 |
Haemoglobin (g/L) | 122 (113–134) | 129 (119–137) | 0.006 |
Urine protein:creatinine ratio (g/mol) | 102 (28–289) | 17 (9–36) | < 0.001 |
- A1 proteinuria (< 15 g/mol) | 16 (10) | 76 (42) | < 0.001 |
- A2 proteinuria (15-50 g/mol) | 44 (26) | 73 (41) | 0.005 |
- A3 proteinuria (> 50 g/mol) | 107 (64) | 30 (17) | < 0.001 |