|
Variables
|
Total (n = 1603)
|
Plasma fibrinogen quartiles
|
P
|
|---|
|
Q1 (< 3.19) (n = 400)
|
Q2 (3.19–3.80) (n = 405)
|
Q3 (3.80–4.72) (n = 398)
|
Q4 (> 4.72) (n = 400)
|
|---|
|
Plasma fibrinogen (g/L)
|
4.12 ± 1.38
|
2.72 ± 0.35
|
3.48 ± 0.18
|
4.26 ± 0.27
|
6.04 ± 1.16
|
< 0.001
|
|
Age (y)
|
47.4 ± 15.3
|
43.9 ± 14.9
|
45.9 ± 15.6
|
47.8 ± 14.5
|
52.1 ± 14.8
|
< 0.001
|
|
Male, n (%)
|
955 (59.6)
|
220 (55.0)
|
234 (57.8)
|
245 (61.6)
|
256 (64.0)
|
0.05
|
|
Smokers, n (%)
|
331 (20.6)
|
65 (16.3)
|
76 (18.8)
|
81 (20.4)
|
109 (27.3)
|
0.001
|
|
History of CV events, n (%)
|
319 (19.9)
|
47 (11.8)
|
61 (15.1)
|
89 (22.4)
|
122 (30.5)
|
< 0.001
|
|
Diabetes, n (%)
|
410 (25.6)
|
49 (12.3)
|
79 (19.5)
|
114 (28.6)
|
168 (42.0)
|
< 0.001
|
|
Hypertension, n (%)
|
1416 (88.3)
|
353 (88.3)
|
358 (88.4)
|
356 (89.4)
|
349 (87.3)
|
0.82
|
|
BMI (kg/m2)
|
22.04 ± 3.29
|
21.15 ± 2.78
|
21.66 ± 3.15
|
22.31 ± 3.19
|
23.07 ± 3.68
|
< 0.001
|
|
SBP (mmHg)
|
154.3 ± 24.8
|
150.4 ± 24.4
|
154.8 ± 23.7
|
157.3 ± 27.2
|
154.8 ± 23.5
|
0.002
|
|
DBP (mmHg)
|
88.4 ± 15.6
|
88.4 ± 16.3
|
88.6 ± 14.8
|
89.6 ± 16.1
|
86.7 ± 15.3
|
0.07
|
|
Hemoglobin (g/L)
|
79.1 ± 18.6
|
78.9 ± 19.1
|
77.9 ± 18.9
|
80.0 ± 18.6
|
79.8 ± 18.0
|
0.36
|
|
Blood platelet count (10 × 109/L)
|
19.3 ± 8.0
|
16.5 ± 6.6
|
17.7 ± 7.2
|
19.8 ± 7.5
|
23.4 ± 8.9
|
< 0.001
|
|
Serum potassium (mmol/L)
|
4.65 ± 0.84
|
4.69 ± 0.83
|
4.73 ± 0.80
|
4.68 ± 0.84
|
4.50 ± 0.86
|
< 0.001
|
|
Serum albumin (g/L)
|
34.8 ± 5.1
|
35.9 ± 5.1
|
35.1 ± 4.7
|
34.7 ± 5.0
|
33.3 ± 5.3
|
< 0.001
|
|
TC (mmol/L)
|
4.72 ± 1.43
|
4.44 ± 1.31
|
4.53 ± 1.13
|
4.91 ± 1.60
|
4.98 ± 1.57
|
< 0.001
|
|
TG (mmol/L)
|
1.30 (0.93–1.88)
|
1.15 (0.80–1.61)
|
1.26 (0.94–1.84)
|
1.32 (0.97–1.88)
|
1.49 (1.02–2.17)
|
< 0.001
|
|
LDL-C (mmol/L)
|
2.83 ± 1.09
|
2.59 ± 0.97
|
2.69 ± 0.85
|
3.00 ± 1.23
|
3.05 ± 1.19
|
< 0.001
|
|
HDL-C (mmol/L)
|
1.05 ± 0.33
|
1.11 ± 0.34
|
1.04 ± 0.32
|
1.05 ± 0.33
|
1.00 ± 0.31
|
< 0.001
|
|
hs-CRP (mg/L)
|
2.23 (0.74–8.49)
|
1.16 (0.44–4.08)
|
1.66 (0.49–6.29)
|
2.91 (1.01–9.50)
|
5.09 (1.47–11.79)
|
< 0.001
|
|
eGFR (mL/min/1.73 m2)
|
5.2 ± 2.4
|
5.3 ± 2.4
|
5.1 ± 2.2
|
5.2 ± 2.6
|
5.3 ± 2.5
|
0.62
|
|
Antiplatelet agents, n (%)
|
182 (11.4)
|
25 (6.3)
|
38 (9.4)
|
46 (11.6)
|
73 (18.3)
|
< 0.001
|
|
Lipid-lowering drugs, n (%)
|
182 (11.4)
|
23 (5.8)
|
40 (9.9)
|
49 (12.3)
|
70 (17.5)
|
< 0.001
|
- Note: Continuous quantitative variables are described as means ± standard deviations or medians (interquartile ranges, 1/4–3/4). Categorical data are described as frequencies (percentages)
- Abbreviations: Q1–Q4 lowest to highest quartile, CV cardiovascular, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG triglycerides, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, hs-CRP hypersensitive C-reactive protein, eGFR estimated glomerular filtration rate
