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Table 1 Baseline characteristics of the study cohort according to plasma fibrinogen quartiles

From: Plasma fibrinogen and mortality in patients undergoing peritoneal dialysis: a prospective cohort study

Variables Total (n = 1603) Plasma fibrinogen quartiles P
Q1 (<  3.19) (n = 400) Q2 (3.19–3.80) (n = 405) Q3 (3.80–4.72) (n = 398) Q4 (>  4.72) (n = 400)
Plasma fibrinogen (g/L) 4.12 ± 1.38 2.72 ± 0.35 3.48 ± 0.18 4.26 ± 0.27 6.04 ± 1.16 <  0.001
Age (y) 47.4 ± 15.3 43.9 ± 14.9 45.9 ± 15.6 47.8 ± 14.5 52.1 ± 14.8 <  0.001
Male, n (%) 955 (59.6) 220 (55.0) 234 (57.8) 245 (61.6) 256 (64.0) 0.05
Smokers, n (%) 331 (20.6) 65 (16.3) 76 (18.8) 81 (20.4) 109 (27.3) 0.001
History of CV events, n (%) 319 (19.9) 47 (11.8) 61 (15.1) 89 (22.4) 122 (30.5) <  0.001
Diabetes, n (%) 410 (25.6) 49 (12.3) 79 (19.5) 114 (28.6) 168 (42.0) <  0.001
Hypertension, n (%) 1416 (88.3) 353 (88.3) 358 (88.4) 356 (89.4) 349 (87.3) 0.82
BMI (kg/m2) 22.04 ± 3.29 21.15 ± 2.78 21.66 ± 3.15 22.31 ± 3.19 23.07 ± 3.68 <  0.001
SBP (mmHg) 154.3 ± 24.8 150.4 ± 24.4 154.8 ± 23.7 157.3 ± 27.2 154.8 ± 23.5 0.002
DBP (mmHg) 88.4 ± 15.6 88.4 ± 16.3 88.6 ± 14.8 89.6 ± 16.1 86.7 ± 15.3 0.07
Hemoglobin (g/L) 79.1 ± 18.6 78.9 ± 19.1 77.9 ± 18.9 80.0 ± 18.6 79.8 ± 18.0 0.36
Blood platelet count (10 × 109/L) 19.3 ± 8.0 16.5 ± 6.6 17.7 ± 7.2 19.8 ± 7.5 23.4 ± 8.9 <  0.001
Serum potassium (mmol/L) 4.65 ± 0.84 4.69 ± 0.83 4.73 ± 0.80 4.68 ± 0.84 4.50 ± 0.86 <  0.001
Serum albumin (g/L) 34.8 ± 5.1 35.9 ± 5.1 35.1 ± 4.7 34.7 ± 5.0 33.3 ± 5.3 <  0.001
TC (mmol/L) 4.72 ± 1.43 4.44 ± 1.31 4.53 ± 1.13 4.91 ± 1.60 4.98 ± 1.57 <  0.001
TG (mmol/L) 1.30 (0.93–1.88) 1.15 (0.80–1.61) 1.26 (0.94–1.84) 1.32 (0.97–1.88) 1.49 (1.02–2.17) <  0.001
LDL-C (mmol/L) 2.83 ± 1.09 2.59 ± 0.97 2.69 ± 0.85 3.00 ± 1.23 3.05 ± 1.19 <  0.001
HDL-C (mmol/L) 1.05 ± 0.33 1.11 ± 0.34 1.04 ± 0.32 1.05 ± 0.33 1.00 ± 0.31 <  0.001
hs-CRP (mg/L) 2.23 (0.74–8.49) 1.16 (0.44–4.08) 1.66 (0.49–6.29) 2.91 (1.01–9.50) 5.09 (1.47–11.79) <  0.001
eGFR (mL/min/1.73 m2) 5.2 ± 2.4 5.3 ± 2.4 5.1 ± 2.2 5.2 ± 2.6 5.3 ± 2.5 0.62
Antiplatelet agents, n (%) 182 (11.4) 25 (6.3) 38 (9.4) 46 (11.6) 73 (18.3) <  0.001
Lipid-lowering drugs, n (%) 182 (11.4) 23 (5.8) 40 (9.9) 49 (12.3) 70 (17.5) <  0.001
  1. Note: Continuous quantitative variables are described as means ± standard deviations or medians (interquartile ranges, 1/4–3/4). Categorical data are described as frequencies (percentages)
  2. Abbreviations: Q1–Q4 lowest to highest quartile, CV cardiovascular, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, TG triglycerides, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, hs-CRP hypersensitive C-reactive protein, eGFR estimated glomerular filtration rate