Table 2 Baseline characteristics in belatacept cohort by status for graft failure at 12 and 24 months censored for death
Patient characteristics | All patients (N = 30) | Functioning graft at 12 months (N = 23) | Graft failure at 12 months (N = 6) | P value | Functioning graft at 24 months (N = 18) | Graft failure at 24 months (N = 9) | P value |
|---|---|---|---|---|---|---|---|
Age (y) | 53.5 ± 26 | 54.0 ± 19 | 43 ± 23 | 0.302 | 51.5 ± 23 | 48 ± 28 | 0.940 |
Donor age (y) | 48.0 ± 23 | 50.0 ± 26 | 44 ± 19 | 0.555 | 45 ± 26 | 48.5 ± 23 | 0.825 |
Gender (m/f) | 20/10 | 15/8 | 4/2 | 1.000 | 12/6 | 5/4 | 0.683 |
Post-transplant diabetes | 3/30 | 3/23 | 0/6 | 1.000 | 3/18 | 0/9 | 0.529 |
BMI | 25.3 ± 4.1 | 24.9 ± 3.9 | 25.4 ± 6.6 | 0.511 | 24.1 ± 5.6 | 25.5 ± 5.6 | 0.194 |
Systolic BP (mmHg) | 134 ± 17 | 138 ± 20 | 131.5 ± 30 | 0.384 | 136.5 ± 21 | 133 ± 16 | 0.348 |
Diastolic BP (mmHg) | 84 ± 10 | 84 ± 10 | 84 ± 31 | 0.581 | 86 ± 11 | 84 ± 18 | 0.691 |
Time after transplantation (m) | 127.5 ± 91.3 | 128 ± 130 | 127.5 ± 52.5 | 0.773 | 133.5 ± 135.5 | 126 ± 35 | 0.275 |
eGFR (mL/min) | 22.5 ± 12 | 24.0 ± 13 | 19.0 ± 10 | 0.302 | 25.5 ± 12 | 18.0 ± 4 | 0.095 |
eGFR < 25 mL/min | 17/30 | 12/23 | 5/6 | 0.354 | 8/18 | 8/9 | 0.042 |
Proteinuria (mg/g creatinine) | 840 ± 1166 | 830 ± 950 | 1256 ± 3211 | 0.302 | 657 ± 1276 | 869 ± 2017 | 0.668 |
Living donor transplants | 8/30 | 6/23 | 2/6 | 1.000 | 4/18 | 3/9 | 0.653 |
pancreas/kidney | 2/30 | – | – | ||||
Immunosuppression | |||||||
 Tacrolimus | 22/30 | 15/23 | 6/6 | 0.148 | 13/18 | 6/9 | 1.000 |
 Cyclosporine A | 8/30 | 8/23 | 0/6 | 0.148 | 5/18 | 3/9 | 1.000 |
 Mycophenolic acid | 27/30 | 20/23 | 6/6 | 1.000 | 16/18 | 9/9 | 0.538 |
 Azathioprin | 2/30 | 2/23 | 0/6 | 1.000 | 1/18 | 0/9 | 1.000 |
 Steroid | 24/30 | 17/23 | 6/6 | 0.295 | 13/18 | 8/9 | 0.628 |
DSA | 14/30 | 11/23 | 2/6 | 0.663 | 8/18 | 4/9 | 1.000 |
h/o any rejection | 15/30 | 10/23 | 5/6 | 0.169 | 7/18 | 7/9 | 0.103 |
aTCMR | 3/30 | 1/23 | 2/6 | 0.100 | 1/18 | 2/9 | 0.250 |
aABMR | 6/30 | 4/23 | 2/6 | 0.575 | 2/18 | 4/9 | 0.136 |
Biopsy scores | |||||||
 glomerular scarring (%) | 30.5 ± 33 | 27 ± 31 | 42 ± 27 | 0.302 | 29 ± 27 | 32 ± 43 | 0.860 |
 cg | 0.0 ± 3.0 | 0.0 ± 3.0 | 1.25 ± 3.0 | 0.694 | 0.0 ± 1.1 | 2.5 ± 3.0 | 0.232 |
 ct | 1.0 ± 1.0 | 1.0 ± 1.0 | 1.0 ± 2.0 | 0.546 | 1.0 ± 1.0 | 1.0 ± 1.0 | 0.348 |
 ci | 1.0 ± 1.0 | 1.0 ± 1.0 | 1.0 ± 2.0 | 0.477 | 1.0 ± 1.0 | 1.0 ± 1.0 | 0.253 |
 cv | 2.0 ± 2.0 | 2.0 ± 2.0 | 1.5 ± 1.0 | 0.427 | 2.0 ± 3.0 | 2.0 ± 1.0 | 0.560 |
 mm | 1.0 ± 2.0 | 1.0 ± 1.0 | 2.0 ± 1.5 | 0.071 | 0.0 ± 1.0 | 2.0 ± 1.5 | 0.067 |
 ah | 3.0 ± 0.0 | 3.0 ± 0.0 | 3.0 ± 0.3 | 0.979 | 0.0 ± 1.0 | 3.0 ± 1.0 | 0.860 |
 g | 0.0 ± 1.0 | 0.0 ± 1.0 | 0.0 ± 1.9 | 0.694 | 0.0 ± 1.0 | 0.0 ± 1.8 | 0.668 |
 t | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 2.0 | 0.384 | 0.0 ± 0.0 | 0.0 ± 1.0 | 0.322 |
 i | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 2.0 | 0.546 | 0.0 ± 0.0 | 0.0 ± 1.0 | 0.781 |
 v | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.000 | 0.0 ± 0.0 | 0.0 ± 0.0 | 1.000 |
 ptc | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.5 ± 3.0 | 0.102 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.067 |
 C4d | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 1.0 | 0.655 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.820 |
 MVI sum score | 0.0 ± 1.3 | 0.0 ± 1.0 | 1.25 ± 3.8 | 0.254 | 0.0 ± 0.0 | 2.0 ± 3.0 | 0.095 |
 MVI sum score ≧2 | 7/30 | 4/23 | 3/6 | 0.131 | 2/18 | 5/9 | 0.023 |