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Fig. 5 | BMC Nephrology

Fig. 5

From: APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress

Fig. 5

APOL1-B3-G2 enhanced podocyte damage and IL-1β production in vivo. a Three days after uninephrectomy, the urine ACR was increased in APOL1-B3-G2 mice compared to wild-type mice and APOL1-B3-G0 mice. b Following uninephrectomy, pro-IL-1β mRNA from isolated glomeruli was upregulated in APOL1-B3-G2 but not in APOL1-B3-G0 mice. Data shown as expression of pro-IL-1β relative to β-actin. c IL-1β levels in the urine, standardized by urine creatinine (Cr) concentration, were found to be significantly higher in APOL1-B3-G2 transgenic mice compared to baseline. Data shown as IL-1β (pg/ml)/Cr (mg/dl). Bars are shown median, asterisk shows p < 0.05

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