Protein energy-wasting associated with nephrotic syndrome – the comparison of metabolic pattern in severe nephrosis to different stages of chronic kidney disease

Table 3 Characteristic of hypercatabolic and less catabolic patients with severe NS

Variable		Hypercatabolic NS n = 9	Less catabolic NS n = 11	p-value
History of NS
short (< 1 month)	n (%)	7 (77.8%)	3 (27.3%)	0.035
long (1–3 months)	n (%)	2 (22.2%)	8 (72.7%)
Age [years]	mean ± SD	37 ± 15	53 ± 16	0.043
Height [cm]	mean ± SD	176 ± 16	172 ± 13	0.380
Weight [kg]	mean ± SD	83 ± 16	83 ± 13	0.910
BMI [kg/m²]	mean ± SD	27.9 ± 3.3	26.6 ± 3.7	0.423
eGFR [mL/min/1.73m²]	mean ± SD	85 ± 28	81 ± 31	0.763
Serum creatinine [mg/dL]	mean ± SD	1.13 ± 0.3	1.14 ± 0.3	0.982
Blood urea [mg/dL]	mean ± SD	70 ± 41	38 ± 13	0.027
Serum albumin [g/dL]	mean ± SD	1.8 ± 0.4	1.9 ± 0.3	0.538
Serum total protein [g/dL]	mean ± SD	4.3 ± 0.4	4.3 ± 0.7	0.703
Proteinuria [g/day]	mean ± SD	11.0 ± 6.2	11.9 ± 2.6	0.688
Prealbumin [mg/dL]	median (IQR)	18 ± 6	26 ± 8	0.018
OH [L]	mean ± SD	8.2 ± 5.8	3.8 ± 1.8	0.030
LTM [kg] adjusted for age	mean ± SD	40.6 ± 2.4	45.8 ± 2.1	0.006*
LTM [kg] adjusted for age	B ± SE (95% CI)	−5.6 ± 1.8 (−9.4; −1.9)	ref	0.006*
BCM [kg] adjusted for age	mean ± SD	22.3 ± 1.6	25.6 ± 1.4	0.007*
BCM [kg] adjusted for age	B ± SE (95% CI)	−3.7 ± 1.22 (−6.2; − 1.2)	ref	0.007*

The average values of continuous variables were presented as mean ± SD or median (OQR). Laboratory parameters were compared between groups using independent samples t-test, and BIS parameters (*) using analysis of covariance (ANCOVA) – after an adjustment for age with less catabolic nephrotic patients as a reference group (ref), and described as coefficient (B) with standard error (SE), 95% confidence interval (95% CI). Statistically significant differences between groups (p-values < 0.05) were bolded

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