Table 4 Top 10 most significantly enriched pathways in Cluster 3 and 4 using IPA^a

Semaphorin signaling in neurons

CFL1,FYN,LIMK2,MET,PAK4,PLXNB1,PTK2,RAC1,RHOBTB1,RHOC,RHOT2,RHOV,RND1,RND3,ROCK1,ROCK2,SEMA4D

mTOR signaling

AKT1,AKT2,AKT3,EIF3B,EIF3D,EIF3E,EIF3F,EIF3H,EIF3J,EIF4A2,FKBP1A,IRS1,KRAS,MAPKAP1,PGF,PLD2,PPP2R2B,PPP2R5C,PRKAG1,PRR5,RAC1,RHOBTB1,RHOC,RHOT2,RHOV,RND1,RND3,RPS10,RPS13,RPS18,RPS2,RPS20,RPS24,RPS5,RPS6KA3,RPS8,RPSA

eIF2 signaling

ACTB,AKT1,AKT2,AKT3,CDK11A,EIF2B1,EIF2B4,EIF3B,EIF3D,EIF3E,EIF3F,EIF3H,EIF3J,EIF4A2,HNRNPA1,KRAS,MYCN,PPP1CA,RPL12,RPL13A,RPL17,RPL24,RPL30,RPL31,RPL35A,RPL7,RPL8,RPS10,RPS13,RPS18,RPS2,RPS20,RPS24,RPS5,RPS8,RPSA,SREBF1,TRIB3

Superpathway of cholesterol biosynthesis

ACAT1,HADHB,HMGCR,HSD17B7,LBR,MVD,MVK,SC5D,SQLE,TM7SF2

Integrin signaling

ACTB,AKT1,AKT2,AKT3,ARF1,ARF4,ARPC2,ARPC3,ARPC5,ARPC5L,BCAR1,BCAR3,CAPN1,CAPN10,FYN,GRB7,ILK,KRAS,NEDD9,PAK4,PTK2,RAC1,RHOBTB1,RHOC,RHOT2,RHOV,RND1,RND3,ROCK1,TLN1,TNK2,TSPAN1,TSPAN4,ZYX

Ephrin receptor signaling

ACP1,AKT1,AKT2,AKT3,ARHGEF15,ARPC2,ARPC3,ARPC5,ARPC5L,BCAR1,CFL1,CREBBP,EFNA1,FGF1,FYN,GNAS,GRINA,KRAS,LIMK2,PAK4,PDGFA,PGF,PTK2,PTPN13,RAC1,ROCK1,ROCK2,SDC2,SH2D3C,STAT3

Apelin muscle signaling pathway

AKT1,AKT2,AKT3,APLNR,GNAS,NOS3,NRF1,PRKAG1

Antigen presentation pathway

CALR,CD74,HLA-A,HLA-DMB,HLA-DOA,HLA-DQB2,HLA-F,MR1,NLRC5,TAP1,TAPBP

Shingosine-1-phosphate signaling

ADCY3,ADCY4,AKT1,AKT2,AKT3,ASAH2B,CASP9,PDGFA,PDGFRB,PLCB1,PLCB4,PLCD1,PTK2,RAC1,RHOBTB1,RHOC,RHOT2,RHOV,RND1,RND3,S1PR1

Regulation of actin-based motility by Rho

ACTB,ARHGDIA,ARPC2,ARPC3,ARPC5,ARPC5L,CFL1,PAK4,PIP5K1A,PIP5K1B,RAC1,RHOBTB1,RHOC,RHOT2,RHOV,RND1,RND3,ROCK1