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Table 1 Participant summary characteristics comparisons for CKD stages 1–2 and CKD stages 3–5

From: Association of retinal venular tortuosity with impaired renal function in the Northern Ireland Cohort for the Longitudinal Study of Ageing

Participant characteristic scr All (n = 1860) CKD stages 1–2 (n = 1713) CKD stages 3–5 (n = 147) P Value
Mean age (years, SD) 62.0 ± 8.5 61.3 ± 8.1 70.5 ± 9.0 < 0.01
Female, n (%) 994 (53.4) 930 (54.3) 64 (43.5) 0.01
Education, primary level and below, n (%) 238 (12.8) 210 (12.6) 28 (19.0) 0.02
Diabetes, yes n (%) 429 (23.1) 380 (22.2) 49 (33.3) < 0.01
Mean BMI (kg/m2, SD) 28.6 ± 5.0 28.5 ± 5.0 29.2 ± 4.4 0.12
Mean systolic blood pressure (mmHg, SD) 131.1 ± 18 131 ± 18 133 ± 19 0.27
Antihypertension medication, yes n (%) 506 (27.2) 438 (25.6) 68 (46.3) < 0.01
Mean triglyceride (mmol/L, SD) 1.7 ± 1.0 1.6 ± 1.0 1.8 ± 0.8 0.11
Mean HDL cholesterol (mmol/L, SD) 1.6 ± 0.5 1.6 ± 0.4 1.5 ± 0.5 < 0.01
Mean LDL cholesterol (mmol/L, SD) 3.5 ± 1.1 3.5 ± 1.1 3.1 ± 1.2 < 0.01
Cardiovascular disease, yes n (%) 143 (7.7) 111 (6.5) 32 (21.8) < 0.01
Mean eGFR Creatinine (mL/min/1.73m2, SD) 82.2 ± 14.9 85.0 ± 11.7 49.6 ± 7.8 < 0.01
Participant characteristic cys All (n = 1860) CKD stages 1–2 (n = 1362) CKD stages 3–5 (n = 498) P Value
Mean age (years, SD) 62.0 ± 8.5 59.8 ± 7.4 68.2 ± 8.3 < 0.01
Female, n (%) 994 (53.4) 739 (54.3) 255 (51.2) 0.24
Education, primary level and below, n (%) 238 (12.8) 138 (10.1) 100 (20.1) < 0.01
Diabetes, yes n (%) 429 (23.1) 271 (19.9) 158 (31.7) < 0.01
Mean BMI (kg/m2, SD) 28.6 ± 5.0 28.0 ± 4.5 30.3 ± 5.6 < 0.01
Mean systolic blood pressure (mmHg, SD) 131.1 ± 18 130 ± 19 133 ± 18 < 0.01
Antihypertension medication, yes n (%) 506 (27.2) 297 (21.8) 209 (42.0) < 0.01
Mean triglyceride (mmol/L, SD) 1.7 ± 1.0 1.6 ± 0.9 1.8 ± 1.0 < 0.01
Mean HDL cholesterol (mmol/L, SD) 1.6 ± 0.5 1.7 ± 0.5 1.6 ± 0.4 < 0.01
Mean LDL cholesterol (mmol/L, SD) 3.5 ± 1.1 3.5 ± 1.1 3.2 ± 1.2 < 0.01
Cardiovascular disease, yes n (%) 143 (7.7) 73 (5.4) 70 (14.1) < 0.01
Mean eGFR Cystatin C (mL/min/1.73m2, SD) 70.7 ± 18.6 78.6 ± 14.7 49.1 ± 8.0 < 0.01
  1. Values are n (%) for categorical variables and mean ± SD for continuous variables. P values were calculated by independent sample t and chi squared tests. Abbreviations: CKD Chronic Kidney Disease, BMI Body Mass Index, eGFR Estimated glomerular filtration rate (calculated using the CKD-EPI equation), HDL High-density Lipoprotein, LDL Low-density Lipoprotein, scr Serum Creatinine, cys Serum Cystatin C, SD Standard deviation
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