Clinical variables | Recovery (n = 22) | Non-recovery; CRRT re-initiation (n = 20) | Non-recovery; Haemodialysis initiation (n = 12) | P-value |
---|---|---|---|---|
Male/female | 16/6 (73%/27%) | 11/9 (55%/45%) | 9/3 (75%/25%) | 0.56 |
Age, years | 77 [42–83] | 70 [51–81] | 68 [30–83] | 0.84 |
BMI, kg/m2 | 26 [19–35] | 27 [19–38] | 25 [24–37] | 0.45 |
SOFA, highest value | 13 [7–18] | 15 [11–19] | 13 [8–21] | 0,20 |
APACHE II | 27 [18–40] | 29 [21–43] | 26 [18–38] | 0.71 |
SAPS II | 56 [30–75] | 65 [44–86] | 58 [38–78] | 0.10 |
Hypertension | 9 (41%) | 11 (55%) | 7 (58%) | 0.76 |
Malignity | 6 (27%) | 10 (50%) | 2 (17%) | 0.56 |
CVVH/CVVHD | 0/22 (0/100%) | 4/16 (20/80%) | 0/12 (0/100%) | 0.14 |
RIFLE-F | 21 (95%)a | 20 (100%) | 12 (100%) | 0.41 |
Furosemide, mg/day | 0 [0–554] | 80 [0–534] | 100 [0–480] | 0.44d |
Mean arterial pressure, mmHg | 69 [62–85] | 70 [63–93] | 78 [59–113] | 0.23 |
Creatinine, μmol/L | 186 [84–621] | 194 [87–531] | 238 [90–765] | 0.99 |
Creatinine clearance, ml/min | 19 [7–45] | 15 [8–27] | 17 [5–26] | 0.11 |
C-Reactive Protein (CRP), mg/L | 216 [7–454] | 139 [13–266] | 108 [34–423] | 0.18 |
Urine output, ml/hour b | 18 [0–50] | 8 [0–97] | 0 [0–52] | 0.40d |
Urine output, ml/day c | 398 [103–1488] | 326 [8–1750] | 120 [13–2550] | 0.23d |
Noradrenaline, μg/kg/min | 0.35 [0.09–1.26] | 0.28 [0.07–1.32] | 0.12 [0.02–1.10] | 0.35d |
Nephrotoxic medicine including contrast. | 8 (36%) | 12 (60%) | 6 (50%) | 0.18 |
Presumed primary cause of AKI: | 0.56 | |||
Prerenal | 8 (36%) | 5 (25%) | 2 (17%) | |
Sepsis | 12 (55%) | 13 (65%) | 4 (33%) | |
Glomerulonephritis | 0 | 0 | 1 (8%) | |
Rhabdomyolysis | 1 (4,5%) | 1 (5%) | 3 (25%) | |
Microthrombosis/vasculitis | 1 (4,5%) | 1 (5%) | 2 (17%) | |
Primary reason for ICU admission: | 0.62 | |||
Septic shock/sepsis | 9 (41%) | 103 (65%) | 6 (51%) | |
Trauma | 1 (5%) | 2 (10%) | 0 | |
AKI | 5 (23%) | 1 (5%) | 2 (17%) | |
Respiratory failure | 4 (18%) | 2 (10%) | 3 (34%) | |
Low cardiac output | 3 (14%) | 2 (10%) | 1 (8%) | |
Urine-NGAL, μg/L | 2645 [279–27,543] | 2894 [749–18,537] | 3619 [128–30,170] | 0.57d |
Time, ICU admission to CRRT initiation/study inclusion, days | 1 [0–7.4] | 2 [0–5.9] | 1 [0–12.1] | 0.94 |