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Table 2 Variables at the time of discontinuation of continuous renal replacement therapy

From: Urine neutrophil gelatinase-associated lipocalin and urine output as predictors of the successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury

Variablep n Recovery (n = 22) Non-recovery; CRRT re-initiation (n = 20) Non-recovery; Haemodialysis initiation (n = 12) p-value
Urine NGAL
 time 0, μg/L 42 1370 [154–8002] 8934 [2095–40,000] 8726 [360–35,449] 0.0003d
 6 h, μg/L 37 465 [56–3978] 2966 [1985–29,011] 2854 [120–6055] 0.0006d
 12 h, μg/L 39 436 [95–3780] 1976 [798–16,972] 2148 [54–3825] 0.0008d
 24 h, μg/L 31 455 [100–3337] 2290 [874–17,665] 295 [32–1624] 0.24d
MAP
 time 0, mmHg 54 80 [67–103] 71 [62–94] 82 [67–96] 0.12
 6 h, mmHg 52 78 [66–105] 73 [66–105] 78 [64–106] 0.30d
 12 h, mmHg 50 75 [67–106] 73 [65–105] 80 [68–103] 0.42
 24 h, mmHg 46 75 [67–106] 75 [67–103] 83 [68–113] 0.60
Furosemide
 6 h., mg 52 70 [0–240] 70 [0–246] 5 [0–240] 0.94
 12 h., mg 50 95 [0–480] 95 [0–480] 65 [0–480] 0.66
 24 h., mg 46 150 [0–853] 240 [15–936] 70 [0–936] 0.50
Use of other diuretics   4 (18%) 4 (20%) 6 (50%) 0.52
Urine output 24 h prior to CRRT (time 0) discontinuation, ml 54 500 [87–2140] 100 [31–533] 20 [0–575] < 0.0001
Urine output after discontinuation
 6 h, ml/hr 52 65 [13–266] 8 [0–47] 3 [0–50] < 0.0001
 12 h, ml/hr 50 85 [27–197] 10 [0–60] 3 [0–54] < 0.0001
 24 h, ml 46 2340 [828–4488] 480 [0–2952] 240 [0–3828] < 0.0001
Time to re-initiation of dialysis, hrs    24 [6–64] 48 [20–71]  
Time on CRRT, days 54 4 [2–10] 8 [4–20] 5 [2–18] 0,001d
Mechanical ventilation, days 54 4 [0–23] 14 [0–32] 2 [0–18] 0.18
ICU, days 54 10 [2–32] 17 [5–38] 9 [3–20] 0.22
Creatinine
 At discontinuation, μmol/L 24 h after 54 98 [51–250] 130 [67–289] 157 [82–314] 0.18
 discontinuation, μmol/L 46 134 [67–340] 191 [119–409] 235 [135–433] 0.03
Creatinine clearance
 At discontinuation, ml/min 24 h after 54 62 [17–90] 43 [21–85] 37 [18–75] 0.08
 discontinuation, ml/min 46 38 [16–82] 28 [15–52] 22 [12–41] 0.02
C-reactive protein (CRP)
 At discontinuation, mg/L 24 h after 54 135 [35–267] 89 [22–260] 80 [16–172] 0.09
 discontinuation, mg/L 46 125 [26–238] 100 [20–320] 65 [13–152] 0.28
  1. P-value was calculated between the recovery and non-recovery (CRRT-re-initiation and haemodialysis) groups. d) Log10 transformation was used to calculate the p-value
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