Fig. 1

Renal histology of the patient. a Most glomeruli show no abnormality by PASM staining. b Among the 32 glomeruli, one reveals global glomerulosclerosis (white arrow heads). (PASM× 200). (Method: Light microscope: OLYMPUS, BX51. Image acquisition system: OLYMPUS, DP72.) (c) EM shows mild hyperplasia of mesangial cells and mesangial matrix. (× 10,000) (d) Proliferation and hypertrophy of mitochondria and crowded arrangement are observed on the lumen plane of renal tubules. (× 8000) (Method: Electron microscope: JEM1230, Japan JEOL Company. Camera: Model 832 digital image transmission instrument (CCD Camera), America Gatan Company)