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Table 1 Polymorphisms of the MYH9 gene associated with CKD traits. Data for variables with P < 0.05 are shown in bold

From: Effect of donor non-muscle myosin heavy chain (MYH9) gene polymorphisms on clinically relevant kidney allograft dysfunction

SNP

risk variant

European Americans non-diabetic [10]

European Americans [16]

Spanish Caucasians [11]

European isolated cohorts [5]

Microsa

Visb

ERFc

Meta-analysis of Micros, VIS, ERF

 

eGFR< 60 ml/min

FSGS

eGFR< 60 ml/min

serum creatinine increment (mg/dl)

OR (95% CI)

p

OR (95% CI)

p

OR (95% CI)

p

b# (SE)

p

b# (SE)

p

b# (SE)

p

b# (SE)

p

rs3752462

T

 

2.42 (1.17–5.04)

.01

1.99 (1.20–3.31)

.007

 

 

 

 

rs11089788

C

 

 

 

−0.0108 (0.0061)

.0782

−0.0204 (0.0143)

.1555

−0.0109 (0.0075)

.1465

−0.0118 (0.0045)

.0089

rs5756168

C

 

 

 

0.0284 (0.0097)

.0034

−0.0436 (0.0255)

.0875

0.0144 (0.0108)

.1839

0.0173 (0.0069)

.0127

rs2239784

T

 

 

 

0.0309 (0.0142)

.0294

−0.0069 (0.0269)

.7983

0.0158 (0.0172)

.3560

−0.0112 (0.0101)

.2674

rs136211

A

 

 

 

−0.0021 (0.0067)

.7502

−0.0406 (0.0162)

.0123

0.01240.0075)

.1009

0.0004 (0.0048)

.9414

rs4821480

G

1.44 (1.15–1.80)

0.001

9.73 (1.07–463)

.02

 

 

 

 

 
  1. table adapted from Liu L et at [16] supplemented with data from Pattaro et al. [12]
  2. #linear regression coefficients (b) and SE, assuming an additive genetic model adjusted for sex and age
  3. aMICROS cohort - The Genetic Study of three Population Microisolates in South Tyrol, Italy
  4. bVis cohort- CROATIA-Vis study
  5. cERF cohort, Erasmus Rucphen Family study, Netherlands