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Table 3 Transplanted kidney eGFR at third and twelve post-transplant months per MYH9 risk variant in additive, recessive and dominant models

From: Effect of donor non-muscle myosin heavy chain (MYH9) gene polymorphisms on clinically relevant kidney allograft dysfunction

  eGFR month 3 eGFR month 12
SNP genotype n Mean ± SD Median Range p Mean ± SD Median Range p
rs11089788 AA 55 46.6 ± 18.6 42.2 15.5–118   49.0 ± 16.9 44.8 19.1–98.6  
AC 105 47.8 ± 16.6 45.2 19.1–98.6 0.535AAvsAC 52.3 ± 19.7 51.6 19.5–162.9 0.224 AAvsAC
CC 47 45.4 ± 12.6 44.1 22.2–78.1 0.627 ACvsCC 48.7 ± 13.8 48.4 12.2–84.2 0.351 ACvsCC
rs11089788 AA 55 46.6 ± 18.6 42.2 15.5–118   49.0 ± 16.9 44.6 19.1–96.8  
AC + CC 152 47.0 ± 15.5 44.6 19.1–96.8 0.574 AAvsC 51.1 ± 18.1 50.8 12.2–162.9 0.273 AAvsC
rs11089788 CC 47 45.5 ± 12.6 44.1 22.2–78.1   48.7 ± 13.8 48.4 12.2–84.2  
AA+AC 160 47.4 ± 17.3 44.4 15.5–118 0.820 CCvsA 51.1 ± 18.8 48.7 19.1–162.9 0.692 CCvsA
rs136211 AA 21 49.4 ± 12.9 46.8 29.0–74.9   52.4 ± 14.4 51.7 22.4–84.2  
AG 91 47.7 ± 14.8 46.3 21.3–91.3 0.467 AAvsAG 50.7 ± 14.8 51.7 12.2–86.2 0.806 AAvsAG
GG 95 45.6 ± 18.3 41.2 15.5–118 0.123 AGvsGG 50.0 ± 21.0 44.8 20.6–162.9 0.139 AGvsGG
rs136211 AA 21 49.4 ± 12.9 46.8 29–74.9   52.4 ± 14.4 51.7 22.4–84.2  
AG + GG 186 46.6 ± 16.7 43.6 15.5–118 0.208 AAvsG 50.4 ± 18.2 48.4 12.2–86.2 0.377 AAvsG
rs136211 GG 95 45.6 ± 18.3 41.2 15.5–118   50.0 ± 21.0 44.8 20.6–162.9  
AG + AA 112 48.0 ± 14.4 46.6 21.3–91.3 0.064 GGvsA 51.0 ± 14.7 51.7 12.2–86.2 0.085 GGvsA
rs3752462 CC 112 45.8 ± 16.6 41.3 15.5–118   49.1 ± 15.9 47.3 19.1–91.3  
CT 79 49.1 ± 16.1 47.3 19.1–91.3 0.077 CCvsCT 52.4 ± 19.8 51.3 19.1–162.9 0.260 CCvsCT
TT 16 44.2 ± 15.1 42.1 27.7–83.7 0.208 CTvsTT 52.0 ± 20.2 50.0 12.2–99.2 0.992 CTvsTT
rs3752462 CC 112 45.8 ± 16.6 41.3 15.5–118   49.1 ± 15.9 47.3 19.1–91.3  
CT + TT 95 48.3 ± 16.0 46.3 19.1–91.3 0.145 CCvsT 52.3 ± 19.8 51.2 12.2–162.9 0.236 CCvsT
rs3752462 TT 16 44.2 ± 15.1 42.1 27.7–83.7   52.0 ± 20.2 50.0 12.2–99.2  
CC + CT 191 47.1 ± 16.4 44.6 15.5–118 0.461 TTvsC 50.5 ± 17.6 48.6 19.1–162.9 0.709 TTvsC
rs5756168 CC 3 53.2 ± 6.0 55.8 46.3–57.3   58.5 ± 22.5 49.2 42.2–84.2  
CT 39 48.3 ± 13.8 47.8 22.2–86.7 0.366 CCvsCT 51.0 ± 12.9 53.0 23.9–77.9 0.771 CCvsCT
TT 165 46.5 ± 17.0 43.5 15.5–118 0.254 CTvsTT 50.3 ± 18.7 47.9 12.2–162.9 0.357 CTvsTT
rs5756168 CC 3 53.2 ± 6.0 55.8 46.3–57.3   58.5 ± 22.5 49.2 42.2–84.2  
CT + TT 204 46.8 ± 16.4 44.2 15.5–118 0.257 CCvsT 50.5 ± 17.8 48.6 12.2–162.9 0.560 CCvsT
rs5756168 TT 165 46.5 ± 17.0 43.5 15.5–118   50.3 ± 18.7 47.9 12.2–162.9  
CC + CT 42 48.7 ± 13.4 48.4 22.2–86.7 0.169 TTvsC 51.5 ± 13.6 52.7 23.9–84.2 0.298 TTvsC
rs2239784 CC 187 46.5 ± 15.6 44.3 15.5–96.8   50.4 ± 18.0 48.8 12.2–182.9  
CT 20 50.9 ± 21.9 46.8 27.7–118 0.569 CCvsCT 52.6 ± 15.6 47.1 32.3–99.2 0.614 CCvsCT
TT 0         
rs2239784 CC 187 46.5 ± 15.6 44.3 15.5–96.8   50.4 ± 18.0 48.8 12.2–182.9  
CT + TT 20 50.9 ± 21.9 46.8 27.7–118 0.569 CCvsT 52.6 ± 15.6 47.1 32.3–99.2 0.614 CCvsT
rs2239784 TT 0         
CC + CT 207 46.9 ± 16.3 44.3 15.5118   50.6 ± 17.8 48.6 12.1162.8  
rs4821480 GG 1 51.6    55.8±    
GT 27 51.8 ± 17.7 49.5 27.5–91.3   54.5 ± 18.3 51.4 30.1–99.2  
TT 179 46.1 ± 16.1 44.1 15.5–118 0.126 GTvsTT 50.0 ± 17.7 48.4 12.2–162.9 0.337 GTvsTT
rs4821480 GG 1 51.6     55.8    
GT + TT 206 46.9 ± 16.4 44.3 15.5118   50.6 ± 17.8 48.6 12.2–162.9  
rs4821480 TT 179 46.1 ± 16.1 44.1 15.5–118   50.0 ± 17.7 48.4 15.5–118  
GG + GT 28 51.8 ± 17.4 49.8 27.5–91.3 0.108 TTvsG 54.6 ± 18.0 51.9 30.1–99.2 0.295 TTvsG