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Table 3 Clinical outcomes after diagnosis of membranous nephropathy

From: Membranous nephropathy in patients with HIV: a report of 11 cases

No.

Treatment

FU (months)

Renal outcome

Last CD4

Last HIV*

Last sCr

Last UPCR (g/g)**

Serum anti-PLA2R***

1

ACEi/ARB; MMF; Pred; ARV then MMF switched to CYC within 1 yr

145

ESRD/Dialysis

806

Undet.

4.4

8.4

NP

2

ACEi/ARB; MMF; Pred; ARV

140

ESRD/Dialysis; Transplant

599

Undet.

7.2

7.2

NP

3

81

Non-ESRD

161

Undet.

0.95

Undet.

NP

4

Discontinuation of Tenofovir

54

Non-ESRD

216

2190

1.27

NP

5

ACEi/ARB; PredTac; then Ritux; mPred

9

Non-ESRD

971

Undet.

1.16

11.9

153 RU/mL

6

ACEi/ARB; Pred; then CYC added

9

Non-ESRD

244

Undet.

2.73

2.02

< 1:10

7

ACEi/ARB

4

Non-ESRD

243

Undet.

1.9

1.0

< 1:10

8

114

Non-ESRD

0.89

NP

9

ACEi/ARB;Pred;CYC

20

ESRD/dialysis

Undet.

NP

10

ACEi/ARB

42

Non-ESRD

Undet.

“normal”

Undet.

NP

11

ACEi/ARB

44

Non-ESRD

1117

Undet.

2.8

0.25

NP

  1. Abbreviations: FU: Follow-up; sCr: serum creatinine; UPCR: urine protein-to-creatinine ratio; MMF: mycophenolate mofetil; Pred: prednisone; ARV: antiretroviral therapy; ACEi/ARB: Angiotensin converting enzyme inhibitor/angiotensin receptor blocker; Tac: Tacrolimus; Ritux: Rituximab; mPred: methylprednisolone; CYC: cyclophosphamide; Undet.: undetectable; NP: Not performed.*Undet. refers to undetectable HIV-1 RNA levels, the lower limit of detection being < 75 copies/mL.**Undet. refers to undetectable urine protein by dipstick analysis. *** < 1:10 refers to a negative titer of serum anti-PLA2R antibodies