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Table 4 Plasma concentrations of vasopressin (p-AVP), renin (PRC), aldosterone (p-Aldo), angiotensin II (p-AngII), and plasma osmolality (p-Osm) during a water deprivation test in patients with adult dominant polycystic kidney disease (ADPKD), patients with non-ADPKD kidney disease (Non-ADPKD), and healthy control subjects (Controls). Urine was collected in four periods. Period 1 (twelve hours): from 0730 PM the day before arrival to the laboratory to 0730 AM on the examination day. Period 2 (one hour): 0730 to 0830 AM. Period 3 (two hours): 0830–1030 AM. Period 4 (two hours): 1030–1230 AM. Blood samples were taken at the end of periods 2, 3 and 4

From: Urine concentration ability is reduced to the same degree in adult dominant polycystic kidney disease compared with other chronic kidney diseases in the same CKD-stage and lower THAN in healthy control subjects - a CASE control study

  End of Period 2
08.30 AM
End of Period 3
10.30 AM
End of Period 4
12.30 AM
P-AVP (pg/ml)
 ADPKD 0.5 ± 0.4 0.6 ± 0.4 0.6 ± 0.4
 Non-ADPKD 0.6 ± 0.4 0.6 ± 0.3 0.6 ± 0.3
 Controls 0.4 ± 0.3 0.4 ± 0.3 0.5 ± 0.3
Comparison within groups 0.753
Comparison between groups 0.317
PRC (pg/ml)
 ADPKD 7.4 [4.3;8.8]# 5.4 [4.1;8.6]# 6.0 [3.6;8.7]#
 Non-ADPKD 12.9 [5.8;26.4] 11.4 [4.9;26.4] 10.6 [4.8;24.8]
 Controls 7.1 [5.9;10.4] 7.4 [4.7;9.7] 6.4 [4.8;8.7]
Kruskal-Wallis test 0.050 0.054 0.079
P-AngII (pg/ml)
 ADPKD 5.5 ± 4.0 5.0 ± 3.1 5.7 ± 3.5
 Non-ADPKD 6.6 ± 3.6 6.1 ± 2.7 6.2 ± 3.2
 Controls 5.7 ± 2.4 6.0 ± 3.3 5.4 ± 3.0
Comparison within groups 0.348
Comparison between groups 0.715
P-Aldo (pmol/l)
 ADPKD 324 [203;478]* 305 [218;484]* 273 [222;385]*
 Non-ADPKD 257 [201;314]* 230 [179;380]* 213 [172;334]*
 Controls 145 [126;223] 120 [99;157] 101 [95;154]
Kruskal-Wallis test < 0.001 < 0.001 < 0.001
P-Osm (mosmol/kg)
 ADPKD 294 ± 4 293 ± 4 293 ± 4
 Non-ADPKD 296 ± 8 296 ± 8 295 ± 7
 Controls 293 ± 4 293 ± 4 292 ± 4
Comparison within groups 0.651
Comparison between groups 0.236
  1. A General Linear Model with Greenhouse-Geisser correction was used for comparison within and between the three groups. Values represent mean ± SD or median with 25 and 75% percentiles in brackets * = p < 0.05 between ADPKD or non-ADPKD- patients and healthy controls. # = p < 0.05 between ADPKD and non-ADPKD- patients