Urine concentration ability is reduced to the same degree in adult dominant polycystic kidney disease compared with other chronic kidney diseases in the same CKD-stage and lower THAN in healthy control subjects - a CASE control study

Table 4 Plasma concentrations of vasopressin (p-AVP), renin (PRC), aldosterone (p-Aldo), angiotensin II (p-AngII), and plasma osmolality (p-Osm) during a water deprivation test in patients with adult dominant polycystic kidney disease (ADPKD), patients with non-ADPKD kidney disease (Non-ADPKD), and healthy control subjects (Controls). Urine was collected in four periods. Period 1 (twelve hours): from 0730 PM the day before arrival to the laboratory to 0730 AM on the examination day. Period 2 (one hour): 0730 to 0830 AM. Period 3 (two hours): 0830–1030 AM. Period 4 (two hours): 1030–1230 AM. Blood samples were taken at the end of periods 2, 3 and 4

A General Linear Model with Greenhouse-Geisser correction was used for comparison within and between the three groups. Values represent mean ± SD or median with 25 and 75% percentiles in brackets * = p < 0.05 between ADPKD or non-ADPKD- patients and healthy controls. # = p < 0.05 between ADPKD and non-ADPKD- patients

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