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Table 2 Urinalysis and autoimmune screen results

From: Histological diagnosis of immune checkpoint inhibitor induced acute renal injury in patients with metastatic melanoma: a retrospective case series report

Patient

Baseline Urinalysis

Urinalysis at AKI

Autoimmune screen

Haematuria

Pyuria

Proteinuria

Culture / Casts

Haematuria

Pyuria

Proteinuria

Culture / Casts

1

-

-

-

-

-

-

-

-

negative

2

NA

NA

NA

NA

-

-

-

-

negative

3

-

+

-

-

-

-

-

-

negative

4

NA

NA

NA

NA

-

+

-

-

negative

5

-

+

-

-

-

+

+

-

Not available

6

NA

NA

NA

NA

-

+

+

-

Not available

7

-

-

-

-

-

+

+

Hyaline casts

ANA 1:2560.

8

NA

NA

NA

NA

+

+

-

E. cloacae UTI

Not available

9

-

-

-

-

-

-

NA

-

negative

10

NA

NA

NA

NA

+

+

N/A

E. Coli infection

anti GBM 614u/mL

11

-

-

-

-

-

-

+

-

ANA 1:80

12

NA

NA

NA

NA

+

+

+

-

negative

13

-

-

-

-

-

-

+

-

negative

14

+

-

-

-

-

+

-

-

negative

15

-

-

-

NA

+

+

+

-

negative

16

+

Nil

+

-

+

+

+

Hyaline casts

ANA 1:40

17

-

-

-

NA

+

+

-

-

Not available

18

-

-

-

-

-

-

-

-

negative

19

-

-

-

-

-

-

-

-

negative

20

+

+

NA

-

+

+

+

-

Negative

21

NA

NA

NA

NA

+

+

-

-

pANCA+ve MPO/PR3 negative

22

+

+

-

-

-

+

-

-

negative

23

-

-

+

NA

-

-

+

-

ANA 1:80

  1. NA – not available. Haematuria – > 10 red cells per high power field on microscopy or > 1+ on urine dipstick. Pyuria – > 10 white cells per high power field on microscopy or > 1+ on urine dip stick. Proteinuria – raised albumin/protein:creatinine ratio or > 1+ protein on urine dip stick. ANA – Anti Nuclear Antibody; ANCA – Anti Neutrophil Cytoplasmic Antibody; antiGBM – Glomerular Basement Membrane; MPO – Myeloperoxidase; PR3 – Proteinase 3