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Table 3 Renal function at baseline, 3, 6 and 12 months following renal IrAE

From: Histological diagnosis of immune checkpoint inhibitor induced acute renal injury in patients with metastatic melanoma: a retrospective case series report

  n Renal function SD p-value in relation to baseline
Baseline Creatinine (μmol/L) 23 89.8 18.5 N/A
Baseline eGFR (mL/min/1.73m2) 73 15 N/A
Peak Creatinine (μmol/L) 23 336.5 285 p = <0.001
Peak eGFR (mL/min/1.73m2) 24 12.4 p = <0.001
Creatinine at 3m (μmol/L) 21 127.4 35.1 p = <0.001
eGFR at 3m (mL/min/1.73m2) 54 17.9 p = <0.001
Creatinine at 6m (μmol/L) 16 132 63.8 p = 0.002
eGFR at 6m (mL/min/1.73m2) 54 22.7 p = 0.002
Creatinine at 12m (μmol/L) 11 107.5 20.9 p = 0.009
eGFR at 12m (mL/min/1.73m2) 63 18.1 p = 0.068
  1. eGFR – estimated glomerular filtration rate. N/A – not available. m – month