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Table 4 Renal biopsy histopathology results

From: Histological diagnosis of immune checkpoint inhibitor induced acute renal injury in patients with metastatic melanoma: a retrospective case series report

Patient

Gloms

Glomeruli

Tubules

Interstitium

Vascular

BG atrophy/fibrosis

IF

EM

1

16

Normal

Tubulitis

Marked inflammation

Mild to moderate afteriosclerosis

Mild

Negative

Dense interstitial lymphocytic and neutrophilic infiltrate and tubulitis.

2

35

Normal

patchy florid tubulitis

Patchy inflammation. mixed multinucleate giant cell granulomas

granulomatous inflammation along vessels

None

Negative

Patchy moderate interstitial fibrosis and oedema. lymphocytes infiltrate and few plasma cells. focal tubulitis.

3

18

2/18 sclerosed. Mild chronic ischaemic change

patchy moderate tubulitis

Mild inflammation

moderate patchy arteriosclerosis and intimal thickening.

Severe

Negative

Interstitial fibrosis and atrophy with ischaemic glomerular change. Tubular intramural lymphocytes.

4

14

2/14 sclerosed. Normal

Occasional tubulitis.

Patchy dense foci of moderate inflammation

moderate arteriosclerosis.

Moderate

IgM - 1+ granular mesangial stain.

Moderate interstitial fibrosis and tubular atrophy. Few interstitial lymphocytes

5

18

2/18 sclerosed. chronic ischaemic change

No tubulitis

Patchy inflammation.

focal arteriolesclerosis.

Moderate

C3 - trace granular mesangial staining.

Mild patchy interstitial fibrosis and tubular atrophy. Mild focal lymphocytic infiltrate with few tubules intramural lymphocytes.

6

8

2/8 sclerosed. chronic ischaemic change

Tubulitis

Moderate to severe inflammation

moderate arteriosclerosis and intimal thickening

Mild

Negative

Patchy moderate interstitial fibrosis and oedema accompanied by a lymphocytic infiltrate with some neutrophils.

7

20

Normal

Tubulitis

Patchy moderate to severe inflammation

moderate arterisclerosis and mild arteriolar change

Mild

Lamda and kappa uptake in intraluminal material. weak C3 interstitial staining,

Predominance of acute tubulointerstitial nephritis. Sub epithelial humps and mesangial dense deposits.

8

11

Hypertensive change

Tubulitis

Diffuse moderate inflammation

moderate arterial fibroelastic intimal thickening.

None

Focal mesangial staining IgM.

N/A

9

11

Normal

Tubulitis

Diffuse severe inflammation

Normal

None

Granular deposition of IgA and C3 in mesangial region.

mesangial hypercellularity.

10

8

1/8 sclerosed

tubular injury

mild to moderate inflammation

mild interstitial arterial fibrosis

Mild

Negative

Patchy interstitial fibrosis and tubular atrophy. diffuse interstitial lymphocytic infiltrate.

11

18

2/18 sclerosed. chronic ischaemic change

Tubulitis and associated non caseiting granulomas

Non-caseating granulomas. Mod-Severe inflammation

Normal

Mild

Negative

Patchy interstitial fibrosis and tubular atrophy.

12

31

Necrotising cellular glomerular crescents

tubular injury and tubulitis

moderate inflammation

Normal

Mild

Linear IgG, Kappa, lamda, fibrinogen. No granular staining.

Cellular crescents. No dense deposits of fibrils

  1. N/A electron microscopy report was not available in 1 patient