Patient | Gloms | Glomeruli | Tubules | Interstitium | Vascular | BG atrophy/fibrosis | IF | EM |
---|---|---|---|---|---|---|---|---|
1 | 16 | Normal | Tubulitis | Marked inflammation | Mild to moderate afteriosclerosis | Mild | Negative | Dense interstitial lymphocytic and neutrophilic infiltrate and tubulitis. |
2 | 35 | Normal | patchy florid tubulitis | Patchy inflammation. mixed multinucleate giant cell granulomas | granulomatous inflammation along vessels | None | Negative | Patchy moderate interstitial fibrosis and oedema. lymphocytes infiltrate and few plasma cells. focal tubulitis. |
3 | 18 | 2/18 sclerosed. Mild chronic ischaemic change | patchy moderate tubulitis | Mild inflammation | moderate patchy arteriosclerosis and intimal thickening. | Severe | Negative | Interstitial fibrosis and atrophy with ischaemic glomerular change. Tubular intramural lymphocytes. |
4 | 14 | 2/14 sclerosed. Normal | Occasional tubulitis. | Patchy dense foci of moderate inflammation | moderate arteriosclerosis. | Moderate | IgM - 1+ granular mesangial stain. | Moderate interstitial fibrosis and tubular atrophy. Few interstitial lymphocytes |
5 | 18 | 2/18 sclerosed. chronic ischaemic change | No tubulitis | Patchy inflammation. | focal arteriolesclerosis. | Moderate | C3 - trace granular mesangial staining. | Mild patchy interstitial fibrosis and tubular atrophy. Mild focal lymphocytic infiltrate with few tubules intramural lymphocytes. |
6 | 8 | 2/8 sclerosed. chronic ischaemic change | Tubulitis | Moderate to severe inflammation | moderate arteriosclerosis and intimal thickening | Mild | Negative | Patchy moderate interstitial fibrosis and oedema accompanied by a lymphocytic infiltrate with some neutrophils. |
7 | 20 | Normal | Tubulitis | Patchy moderate to severe inflammation | moderate arterisclerosis and mild arteriolar change | Mild | Lamda and kappa uptake in intraluminal material. weak C3 interstitial staining, | Predominance of acute tubulointerstitial nephritis. Sub epithelial humps and mesangial dense deposits. |
8 | 11 | Hypertensive change | Tubulitis | Diffuse moderate inflammation | moderate arterial fibroelastic intimal thickening. | None | Focal mesangial staining IgM. | N/A |
9 | 11 | Normal | Tubulitis | Diffuse severe inflammation | Normal | None | Granular deposition of IgA and C3 in mesangial region. | mesangial hypercellularity. |
10 | 8 | 1/8 sclerosed | tubular injury | mild to moderate inflammation | mild interstitial arterial fibrosis | Mild | Negative | Patchy interstitial fibrosis and tubular atrophy. diffuse interstitial lymphocytic infiltrate. |
11 | 18 | 2/18 sclerosed. chronic ischaemic change | Tubulitis and associated non caseiting granulomas | Non-caseating granulomas. Mod-Severe inflammation | Normal | Mild | Negative | Patchy interstitial fibrosis and tubular atrophy. |
12 | 31 | Necrotising cellular glomerular crescents | tubular injury and tubulitis | moderate inflammation | Normal | Mild | Linear IgG, Kappa, lamda, fibrinogen. No granular staining. | Cellular crescents. No dense deposits of fibrils |