Serum neutrophil gelatinase-associated lipocalin at 3 hours after return of spontaneous circulation in patients with cardiac arrest and therapeutic hypothermia: early predictor of acute kidney injury

Table 2 Clinical characteristics after return of spontaneous circulation

	Total		Acute kidney injury					Neurologic outcome at discharge
	Total		(−)		(+)		p-value	Good		Poor		p-value
NGAL at ROSC	124.0	(96.0–186.0)	105.5	(83.3–143.3)	142.0	(107.0–263.0)	0.001	105.0	(84.0–141.0)	140.0	(140.6–245.8)	0.002
NGAL at 3 h after ROSC	181.0	(115.0–381.0)	115.0	(84.3–145.5)	353.0	(223.0–510.0)	< 0.001	134.0	(84.0–181.0)	255.5	(139.5–434.8)	< 0.001
CRRT	11	(14.7)	0	(0.0)	11	(23.4)	0.005	1	(3.6)	10	(23.1)	0.045
CAG	40	(44.9)	25	(62.5)	15	(30.6)	0.003	30	(85.7)	10	(18.5)	< 0.001
Target temperature							0.586					0.559
33 °C	86	(96.6)	38	(95.0)	48	(98.0)		33	(94.3)	53	(98.1)
< 36 °C	3	(3.4)	2	(5.0)	1	(2.0)		2	(5.7)	1	(1.9)
TTM duration							0.624					1.000
24 h	85	(95.5)	39	(97.5)	46	(93.9)		34	(97.1)	51	(94.4)
48 h	4	(4.5)	1	(2.5)	3	(6.1)		1	(2.9)	3	(5.6)
Survival discharge	48	(53.9)	34	(85.0)	14	(28.6)	< 0.001	35	(100.0)	13	(24.1)	< 0.001
CPC at discharge							< 0.001
Good (1,2)	35	(39.3)	26	(65.0)	9	(18.4)
Poor (3,4,5)	54	(60.7)	14	(35.0)	40	(81.6)
Survival at 1 month	47	(52.8)	33	(82.5)	14	(28.6)	< 0.001	35	(100.0)	12	(22.2)	< 0.001
Survival at 6 months	47	(53.4)	33	(82.5)	14	(29.2)	< 0.001	35	(100.0)	12	(22.6)	< 0.001

Quantitative data are expressed as median (interquartile range), categorical data are presented as number of subjects (percentages). Mann-Whitney U test was used for continuous variable analysis, while chi-squared test or Fisher’s exact test were used for categorical variable analysis as appropriate
NGAL neutrophil gelatinase-associated lipocalin, ROSC return of spontaneous circulation, CRRT continuous renal replacement therapy, CAG coronary angiography, TTM targeted temperature management, CPC cerebral performance category

ISSN: 1471-2369