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Table 2 Clinical characteristics after return of spontaneous circulation

From: Serum neutrophil gelatinase-associated lipocalin at 3 hours after return of spontaneous circulation in patients with cardiac arrest and therapeutic hypothermia: early predictor of acute kidney injury

  Total Acute kidney injury Neurologic outcome at discharge
(−) (+) p-value Good Poor p-value
NGAL at ROSC 124.0 (96.0–186.0) 105.5 (83.3–143.3) 142.0 (107.0–263.0) 0.001 105.0 (84.0–141.0) 140.0 (140.6–245.8) 0.002
NGAL at 3 h after ROSC 181.0 (115.0–381.0) 115.0 (84.3–145.5) 353.0 (223.0–510.0) < 0.001 134.0 (84.0–181.0) 255.5 (139.5–434.8) < 0.001
CRRT 11 (14.7) 0 (0.0) 11 (23.4) 0.005 1 (3.6) 10 (23.1) 0.045
CAG 40 (44.9) 25 (62.5) 15 (30.6) 0.003 30 (85.7) 10 (18.5) < 0.001
Target temperature        0.586      0.559
 33 °C 86 (96.6) 38 (95.0) 48 (98.0)   33 (94.3) 53 (98.1)  
 < 36 °C 3 (3.4) 2 (5.0) 1 (2.0)   2 (5.7) 1 (1.9)  
TTM duration        0.624      1.000
 24 h 85 (95.5) 39 (97.5) 46 (93.9)   34 (97.1) 51 (94.4)  
 48 h 4 (4.5) 1 (2.5) 3 (6.1)   1 (2.9) 3 (5.6)  
Survival discharge 48 (53.9) 34 (85.0) 14 (28.6) < 0.001 35 (100.0) 13 (24.1) < 0.001
CPC at discharge        < 0.001      
 Good (1,2) 35 (39.3) 26 (65.0) 9 (18.4)       
 Poor (3,4,5) 54 (60.7) 14 (35.0) 40 (81.6)       
Survival at 1 month 47 (52.8) 33 (82.5) 14 (28.6) < 0.001 35 (100.0) 12 (22.2) < 0.001
Survival at 6 months 47 (53.4) 33 (82.5) 14 (29.2) < 0.001 35 (100.0) 12 (22.6) < 0.001
  1. Quantitative data are expressed as median (interquartile range), categorical data are presented as number of subjects (percentages). Mann-Whitney U test was used for continuous variable analysis, while chi-squared test or Fisher’s exact test were used for categorical variable analysis as appropriate
  2. NGAL neutrophil gelatinase-associated lipocalin, ROSC return of spontaneous circulation, CRRT continuous renal replacement therapy, CAG coronary angiography, TTM targeted temperature management, CPC cerebral performance category
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